Shopping Cart
- Remove All
Your shopping cart is currently empty
CR4056
🥰Excellent
Catalog No. T15010Cas No. 1004997-71-0
Alias 6-(1H-imidazol-1-yl)-2-phenylquinazoline
CR4056 (6-(1H-imidazol-1-yl)-2-phenylquinazoline) is a selective inhibitor of MAO-A with IC50 of 202.7 nM and a ligand of I2-imidazoline receptor with IC50 of 596 nM.
CR4056
🥰Excellent
Purity: 99.53%
Catalog No. T15010Alias 6-(1H-imidazol-1-yl)-2-phenylquinazolineCas No. 1004997-71-0
CR4056 (6-(1H-imidazol-1-yl)-2-phenylquinazoline) is a selective inhibitor of MAO-A with IC50 of 202.7 nM and a ligand of I2-imidazoline receptor with IC50 of 596 nM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $117 | In Stock | |
| 5 mg | $262 | In Stock | |
| 10 mg | $388 | In Stock | |
| 25 mg | $616 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "CR4056"
Paeonol
Peonol
T2900552-41-0
Paeonol (Peonol) is an active extraction from Paeonia suffruticosa. Paeonol inhibits MAO-A and MAO-B with IC50 of 54.6 μM and 42.5 μM, respectively.
- $46
Size
QTY
Allantoin
Glyoxyldiureide, 5-Ureidohydantoin
T092597-59-6
Allantoin (Glyoxyldiureide), a urea hydantoin found in urine and plants, is used in dermatological preparations.
- $40
Size
QTY
Hydroxyamine hydrochloride
Hydroxylammonium chloride, Hydroxylamine hydrochloride
T115875470-11-1
Hydroxyamine hydrochloride(Hydroxylammonium chloride) is a selective and potent monoamine oxidase (MAO) inhibitor with inhibitory effects on platelet aggregation.Hydroxyamine hydrochloridee is an intermediate in organic synthesis and can be used to synthesize other active compounds.
- $31
Size
QTY
Azure B
Azure B chloride
T18918531-55-5
Azure B (Azure B chloride) is a cationic dye and the major metabolite of Methylene blue. Azure B is a selective, and reversible inhibitor of MAO-A (IC50s: 11 and 968 nM for recombinant human MAO-A and MAO-B).
- $128
Size
QTY
Safinamide
FCE-26743, FCE26743, FCE 26743, EMD-1195686, EMD1195686, EMD 1195686
T6651L133865-89-1
Safinamide (FCE-26743) is a reversible and selective monoamine oxidase B (IC50 0.098μM) inhibitor, reducing the degradation of dopamine, and a glutamate release inhibitor (IC50 8μM). It also inhibits dopamine reuptake. Safinamide also blocks sodium and calcium channels. Potential additional uses of Safinamide might be Parkinson's disease, restless leg syndrome and epilepsy.
- $31
Size
QTY
Hydralazine hydrochloride
Hydralazine HCl, Apresoline
T1613304-20-1
Hydralazine hydrochloride (Apresoline) is the hydrochloride salt of hydralazine, a phthalazine derivative with antihypertensive and potential antineoplastic activities. Hydralazine alters intracellular calcium release and interferes with smooth muscle cell calcium influx, resulting in arterial vasodilatation. This agent also inhibits the phosphorylation of myosin protein and chelation of trace metals required for smooth muscle contraction, resulting in an increase in heart rate, stroke volume, and cardiac output. In addition to its cardiovascular effects, hydralazine inhibits DNA methyltransferase, which may result in inhibition of DNA methylation in tumor cells.
- $36
Size
QTY
Isatin
Pseudoisatin, Indoline-2,3-dione, 2,3-Indolinedione
T686291-56-5
Isatin (2,3-Indolinedione) is an endogenous MAO inhibitor.
- $29
Size
QTY
Furazolidone
Cited
Furoxone
T075167-45-8
Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM. It is antibacterial and antiprotozoal activity,
- $40
Size
QTY
Cited1,4-Naphthoquinone Cited
α-Naphthoquinone, P-Naphthoquinone, para-naphthoquinone, Naphthalene-1,4-Dione
T7048130-15-4
1,4-Naphthoquinone (P-Naphthoquinone) was used as a potential inhibitor of monoamine oxidase and DNA topoisomerase activities[2]. It was also used to inhibit the acetyltransferase activity[1].
- $31
Size
QTY
CitedAllylthiourea
Thiosinamine, N-Allylthiourea
T0418109-57-9
Allylthiourea (Thiosinamine), a metabolic inhibitor, specifically suppresses ammonia oxidation.
- $29
Size
QTY
Linezolid
PNU-100766
T0391165800-03-3
Linezolid (PNU-100766), the first of the oxazolidinone class, is a synthetic antibiotic used for the therapy of infections resulted from multi-resistant bacteria including methicillin-resistant Staphylococcus aureus (MRSA) and streptococcus. The drug takes effect as the inhibitor of the initiation of bacterial protein synthesis.
- $43
Size
QTY
Rosmarinic acid Cited
Rosemary acid, Labiatenic acid
T276520283-92-5
Rosmarinic acid (Labiatenic acid) is widely found in plants and has antioxidant, anti-inflammatory, and antibacterial activities. It inhibits MAO-A, MAO-B, and COMT with IC50 of 50.1, 184.6, and 26.7 μM respectively.
- Inquiry Price
Size
QTY
CitedSelect Batch
Purity:99.53%
Contact us for more batch information
With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | CR4056 (6-(1H-imidazol-1-yl)-2-phenylquinazoline) is a selective inhibitor of MAO-A with IC50 of 202.7 nM and a ligand of I2-imidazoline receptor with IC50 of 596 nM. |
| Targets&IC50 | MAO-A:202.7 nM, I2R:596 nM |
| In vitro | The co-treatment of CR4056 (3-30 μM) with Bortezomib does not induce any significant difference in cell survival compared with BTZ-treated cells, either in H929 or in RPMI 8226 myeloma cells[1]. |
| In vivo | CR4056 (30 mg/kg) completely reverses the effect of capsaicin, increasing the paw withdrawal threshold (PWT) to 239. CR4056 obviously increases the mechanical withdrawal thresholds of both ipsilateral (F[4, 30]=19.97) and contralateral (F[4, 30]=31.58) hind paws. CR4056 dose-dependently reduces mechanical hyperalgesia with ED50 of 5.8 mg/kg. CR4056 dose-dependently decreases streptozotocin (STZ)-induced diabetic pain in rats (F[4, 35]=31.27). CR4056 (20 mg/kg; oral) increases endogenous norepinephrine (NE) levels by 68.2% in the parieto-occipital cortex. CR4056 (20 mg/kg; p.o.) obviously increases NE levels both in the cerebral cortex (63.1%) and in the lumbar spinal cord (51.3%). CR4056 (10 mg/kg) and Piroxicam (10 mg/kg) obviously reverse the decrease in the withdrawal threshold caused by Capsaicin[2]. |
| Alias | 6-(1H-imidazol-1-yl)-2-phenylquinazoline |
| Molecular Weight | 272.3 |
| Formula | C17H12N4 |
| Cas No. | 1004997-71-0 |
| Smiles | C12=C(N=C(N=C1)C3=CC=CC=C3)C=CC(=C2)N4C=CN=C4 |
| Relative Density. | 1.25 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (165.26 mM), Sonication is recommended.  H2O: < 0.1 mg/mL (insoluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy CR4056 | purchase CR4056 | CR4056 cost | order CR4056 | CR4056 chemical structure | CR4056 in vivo | CR4056 in vitro | CR4056 formula | CR4056 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.