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2-Chloroadenosine
🥰Excellent
Catalog No. T7736Cas No. 146-77-0
2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively)
2-Chloroadenosine
🥰Excellent
Purity: 99.24%
Catalog No. T7736Cas No. 146-77-0
2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively)
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $43 | In Stock | |
| 25 mg | $64 | In Stock | |
| 50 mg | $79 | In Stock | |
| 100 mg | $133 | In Stock | |
| 500 mg | $336 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $30 | In Stock |
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Theophylline monohydrate
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Theophylline monohydrate (Quibron) appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize adenosine. Theophylline monohydrate is a natural alkaloid derivative of xanthine isolated from the plants Camellia sinensis and Coffea arabica. Physiologically, this agent relaxes the bronchial smooth muscle, produces vasodilation (except in cerebral vessels), stimulates the CNS, stimulates the cardiac muscle, induces diuresis, and increases gastric acid secretion; it may also suppress inflammation and improve contractility of the diaphragm.
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Purity:99.24%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | 2-Chloroadenosine (CADO) is a metabolically stable analog of adenosine that binds to adenosine A1, A2A, and A3 receptors( Ki:300, 80, and 1,900 nM, respectively) |
| Targets&IC50 | A2A:80nM(Ki) , A1:300nM(Ki) , A3:1,900 nM(Ki) |
| In vivo | 2-Chloroadenosine(CADO) has been used to activate adenosine receptors in the thalamus, generating anticonvulsive activity in a rat model of generalized seizures.?It has also been used to induce bronchoconstrictor effects in a guinea pig model of asthma and to study cardiovascular responses in normotensive and hypertensive rats |
| Molecular Weight | 301.69 |
| Formula | C10H12ClN5O4 |
| Cas No. | 146-77-0 |
| Smiles | NC1=C2N=CN(C3OC(CO)C(O)C3O)C2=NC(Cl)=N1 |
| Relative Density. | 2.19 g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (149.16 mM)  | |||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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