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25-Hydroxycholesterol

Catalog No. T4717   CAS 2140-46-7

25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

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25-Hydroxycholesterol Chemical Structure
25-Hydroxycholesterol, CAS 2140-46-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 45.00
10 mg In stock $ 61.00
25 mg In stock $ 93.00
50 mg In stock $ 142.00
100 mg In stock $ 223.00
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Purity: 99.78%
Purity: 99.7%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 25-Hydroxycholesterol is a steroid derivative that suppresses the cleavage of sterol regulatory element binding proteins (SREBPs). It inhibits HMG-CoA reductase and so it also plays a significant role in the in vivo regulation of cholesterol biosynthesis after an acute dietary cholesterol challenge. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.
Molecular Weight 402.65
Formula C27H46O2
CAS No. 2140-46-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 20 mg/mL

Chloroform: 50 mg/mL

TargetMolReferences and Literature

1. McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88(6):1071-2.

TargetMolCitations

1. Lan Q, Wang C, Zhou J, et al. 25-Hydroxycholesterol-Conjugated EK1 Peptide with Potent and Broad-Spectrum Inhibitory Activity against SARS-CoV-2, Its Variants of Concern, and Other Human Coronaviruses. International Journal of Molecular Sciences. 2021, 22(21): 11869. 2. Zhang L, Yi Y, Wang T, et al.25-Hydroxycholesterol inhibits classical swine fever virus entry into porcine alveolar macrophages by depleting plasma membrane cholesterol.Veterinary Microbiology.2023: 109668.

Related compound libraries

This product is contained In the following compound libraries:
Human Endogenous Metabolite Library Anti-Metabolism Disease Compound Library Metabolism Compound Library Bioactive Compounds Library Max Anti-Hypertension Compound Library Natural Product Library for HTS Human Endogenous Metabolite Compound Library Plus Bioactive Lipid Compound Library Natural Product Library Anti-Cardiovascular Disease Compound Library

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Keywords

25-Hydroxycholesterol 2140-46-7 Metabolism Others HMG-CoA Reductase Endogenous Metabolite Inhibitor inhibit 25Hydroxycholesterol 25 Hydroxycholesterol inhibitor

 

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