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2OH-BNPP1

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Purity:99.71%

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COA HNMR HPLC

2OH-BNPP1

Catalog No. T14022Cas No. 833481-73-5

2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.

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Pack Size	Price	Availability
1 mg	$63	In Stock
2 mg	$90	In Stock
5 mg	$161	In Stock
10 mg	$283	In Stock
25 mg	$583	In Stock
50 mg	$833	In Stock
100 mg	$1,150	In Stock
1 mL x 10 mM (in DMSO)	$171	In Stock

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Product Introduction

Bioactivity

Description	2OH-BNPP1 is a BUB1 kinase, a Ser/Thr kinase inhibitor, it used for the treatment of cancer.
In vitro	2OH-BNPP1 disrupts TGFβ signaling by hindering the phosphorylation of key proteins involved in both the canonical and non-canonical TGFβ pathways across a variety of cancerous and normal cell lines in a dose-dependent manner[1]. At concentrations ranging from 0.1 to 50 μM, it effectively suppresses TGFβ signaling in a dose-dependent fashion.
In vivo	2OH-BNPP1 (50 mg/kg) blocks TGFβ signaling in vivo as well as significantly decreases the abundance of phosphorylated SMAD2 in tumor-bearing mice[1].

Chemical Properties

Molecular Weight	297.36
Formula	C16H19N5O
Cas No.	833481-73-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: ≥ 100 mg/mL (336.30 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3629 mL	16.8146 mL	33.6293 mL	168.1464 mL
5 mM	0.6726 mL	3.3629 mL	6.7259 mL	33.6293 mL
10 mM	0.3363 mL	1.6815 mL	3.3629 mL	16.8146 mL
20 mM	0.1681 mL	0.8407 mL	1.6815 mL	8.4073 mL
50 mM	0.0673 mL	0.3363 mL	0.6726 mL	3.3629 mL
100 mM	0.0336 mL	0.1681 mL	0.3363 mL	1.6815 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc