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Methylnissolin is a natural product isolated from Astragalus membranaceus that inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. It inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibiting the ERK1/2 MAP kinase cascade. It also inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinases and has antibacterial and anticancer effects.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $81 | In Stock | |
5 mg | $213 | In Stock | |
10 mg | $328 | In Stock | |
25 mg | $552 | In Stock | |
50 mg | $787 | In Stock | |
1 mL x 10 mM (in DMSO) | $195 | In Stock |
Description | Methylnissolin is a natural product isolated from Astragalus membranaceus that inhibits platelet-derived growth factor (PDGF)-BB-induced cell proliferation with an IC50 of 10 μM. It inhibits PDGF-BB-induced vascular smooth muscle cell proliferation by inhibiting the ERK1/2 MAP kinase cascade. It also inhibits PDGF-BB-induced phosphorylation of extracellular signal-regulated kinase 1/2 (ERIC1/2) mitogen-activated protein (MAP) kinases and has antibacterial and anticancer effects. |
Targets&IC50 | PDGFR:10 μM (IC50) |
Alias | 3-Hydroxy-9,10-dimethoxyptercarpan |
Molecular Weight | 300.31 |
Formula | C17H16O5 |
Cas No. | 73340-41-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (83.25 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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