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4-Hydroxyderricin

Catalog No. T10146 CAS 55912-03-3

4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.

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4-Hydroxyderricin, CAS 55912-03-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	4-Hydroxyderricin, a potent and selective MAO-B inhibitor (IC50: 3.43 μM), is the main active ingredient of Angelica sinensis, which mildly inhibits dopamine β-hydroxylase (DBH) activity and possesses antidepressant activity.
Targets&IC50	MAO-B:3.43 μM
In vitro	4-Hydroxyderricin (100 microM) inhibited DNA synthesis in LLC cells, but it had no effect on the DNA synthesis in human umbilical vein endothelial cells (HUVECs) or on the adherence of LLC cells to HUVECs. 4-hydroxyderricin (50 mg/kg x 2/day) inhibited the reduction of the numbers of lymphocytes, CD4+, CD8+ and natural killer (NK)-T cells in the spleen of tumor-removed mice.[2]
In vivo	4-Hydroxyderricin (50 mg/kg x 2/day; oral) inhibited the tumor growth in subcutaneous LLC-implanted mice and inhibited the lung metastasis and prolonged the survival time in mice after the removal of subcutaneous tumors by surgical operation.[2] 4-Hydroxyderricin (10 to 100 microM) inhibited Matrigel-induced formation of capillary-like tubes by HUVECs.[2] The weights of the spleen and thymus in mice with subcutaneously implanted LLC were maintained close to those of normal mice by orally administered 4-hydroxyderricin.[2]

Molecular Weight	338.4
Formula	C21H22O4
CAS No.	55912-03-3

Storage

store at low temperature

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 90.0 mg/mL (266.0 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Kim JH, et al. Xanthoangelol and 4-Hydroxyderricin Are the Major Active Principles of the Inhibitory Activities against Monoamine Oxidases on Angelica keiskei K. Biomol Ther (Seoul). 2013 May 30;21(3):234-40. 2. Kimura Y, et al. Antitumor and antimetastatic activities of 4-hydroxyderricin isolated from Angelica keiskei roots. Planta Med. 2004;70(3):211-219. 3. Sumiyoshi M, et al. Antitumor and antimetastatic actions of xanthoangelol and 4-hydroxyderricin isolated from Angelica keiskei roots through the inhibited activation and differentiation of M2 macrophages. Phytomedicine. 2015;22(7-8):759-767. 4. Akihisa T, et al. 4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells. J Oleo Sci. 2011;60(2):71-77. 5. Nakamura T, et al. Absorption and metabolism of 4-hydroxyderricin and xanthoangelol after oral administration of Angelica keiskei (Ashitaba) extract in mice. Arch Biochem Biophys. 2012;521(1-2):71-76.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

4-Hydroxyderricin 55912-03-3 Metabolism Neuroscience Dehydrogenase MAO 4Hydroxyderricin 4 Hydroxyderricin Inhibitor inhibitor inhibit

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