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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $55 | In Stock | |
2 mg | $77 | In Stock | |
5 mg | $122 | In Stock | |
10 mg | $213 | In Stock | |
25 mg | $379 | In Stock | |
50 mg | $569 | In Stock | |
100 mg | $817 | In Stock | |
500 mg | $1,680 | In Stock | |
1 mL x 10 mM (in DMSO) | $133 | In Stock |
Description | 5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite derived from progesterone, capable of being synthesized by androgen-responsive prostate cancer cells under conditions of starvation. |
In vitro | In human fibroblasts, progesterone is metabolized into 5α-pregnane-3β,6α-diol-20-one [1]. Similarly, in the C4.2 cell line, pregnenolone and progesterone are efficiently converted into 5α-pregnan-3β,6α-diol-20-one, with the process reaching near-complete levels after 24 hours and 18 hours, respectively. This process of preferentially producing 5α-pregnan-3β,6α-diol-20-one from early steroid precursors does not rely on CYP17A1 but is instead contingent on the activity of 3β-HSD [2]. |
Molecular Weight | 334.49 |
Formula | C21H34O3 |
Cas No. | 21853-11-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (298.96 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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