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5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
2 mg | $55 | In Stock | |
5 mg | $91 | In Stock | |
10 mg | $133 | In Stock | |
25 mg | $223 | In Stock | |
50 mg | $333 | In Stock | |
100 mg | $498 | In Stock | |
1 mL x 10 mM (in DMSO) | $92 | In Stock |
Description | 5-OHdU (5-OHdU) is a major oxidation product of 2'-Deoxycytidine and can be incorporated into DNA in vitro. |
In vitro | Translesion synthesis past 5-OHdU in 18- and 45-member oligodeoxyribonucleotides occurred, but pauses both opposite, and one nucleotide prior to, the modified base in the template is observed. The specificity of nucleotide incorporation opposite 5-OHdU in the template is sequence context-dependent. In one sequence context, dA is the principal nucleotide incorporated opposite 5-OHdU. However, in a second sequence context, dC is the predominant base incorporated opposite 5-OHdU. In that same sequence context, dC is also the predominant nucleotide incorporated opposite 5-OHdU[1]. |
Alias | 5-OHdU |
Molecular Weight | 244.2 |
Formula | C9H12N2O6 |
Cas No. | 5168-36-5 |
Smiles | OC[C@H]1O[C@H](C[C@@H]1O)n1cc(O)c(=O)[nH]c1=O |
Relative Density. | 1.31g/cm3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 30 mg/mL (122.9 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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