Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

7-Epi 10-desacetyl paclitaxel

7-Epi 10-desacetyl paclitaxel
7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
Catalog No. T5738Cas No. 78454-17-8
Select Batch
Purity:98.05%
Contact us for more batch information

Resource Download

7-Epi 10-desacetyl paclitaxel

Purity: 98.05%
Catalog No. T5738Alias 7-Epi-10-deacetyltaxol, 10-Deacetyl-7-epipaclitaxelCas No. 78454-17-8

7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
Pack SizePriceAvailabilityQuantity
10 mg$110In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "7-Epi 10-desacetyl paclitaxel"

Product Introduction

Bioactivity
Description
7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.
In vitro
7-Epi-10-deacetyltaxol(EDT) exhibited significant in vitro cytotoxicity in HepG2 cells.Nuclear condensation and DNA fragmentation were observed in cells treated with fungal EDT.?Besides, the fungal EDT arrested HepG2 cells at G2/M phase of cell cycle.?Furthermore, fungal EDT induced apoptosis in HepG2 cells in a dose-dependent manner associated with ROS generation and increased Bax/Bcl-2 ratio, p38 MAPKs and PARP cleavage[1].
Cell Research
The endophytic fungus was identified by traditional and molecular taxonomical characterization and the fungal 7-Epi-10-deacetyltaxol(EDT) was purified using column chromatography and confirmed by various spectroscopic and chromatographic comparisons with authentic paclitaxel.?Studied the in vitro effects of EDT on HepG2 cells for parameters such as cell cycle distribution, DNA fragmentation, reactive oxygen species (ROS) generation and nuclear morphology.?Further, western blot analysis was used to evaluate Bcl-2-associated X protein (Bax), B-cell lymphoma 2 (Bcl-2), p38-mitogen activated protein kinase (MAPK) and poly [ADP-ribose] polymerase (PARP) expression[1].
Alias7-Epi-10-deacetyltaxol, 10-Deacetyl-7-epipaclitaxel
Chemical Properties
Molecular Weight811.87
FormulaC45H49NO13
Cas No.78454-17-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 8.11 mg/mL (9.99 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.2317 mL6.1586 mL12.3172 mL61.5862 mL
5 mM0.2463 mL1.2317 mL2.4634 mL12.3172 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy 7-Epi 10-desacetyl paclitaxel | purchase 7-Epi 10-desacetyl paclitaxel | 7-Epi 10-desacetyl paclitaxel cost | order 7-Epi 10-desacetyl paclitaxel | 7-Epi 10-desacetyl paclitaxel chemical structure | 7-Epi 10-desacetyl paclitaxel in vitro | 7-Epi 10-desacetyl paclitaxel formula | 7-Epi 10-desacetyl paclitaxel molecular weight