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A-935142

Catalog No. T14077Cas No. 1031335-85-9

A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator that enhances hERG currents by slowing inactivation, promoting activation, reducing inactivation, and shortening atrial and ventricular repolarization in a complex manner.

A-935142

A-935142

Purity: 100%
Catalog No. T14077Cas No. 1031335-85-9
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator that enhances hERG currents by slowing inactivation, promoting activation, reducing inactivation, and shortening atrial and ventricular repolarization in a complex manner.
Pack SizePriceAvailabilityQuantity
1 mg$350In Stock
5 mg$828In Stock
10 mg$1,130In Stock
25 mg$1,590In Stock
50 mg$1,980In Stock
100 mg$2,500In Stock
500 mg$4,900In Stock
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Purity:100%
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Product Introduction

Bioactivity
Description
A-935142 is a human ether-a-go-go-related gene (hERG, Kv 11.1) channel activator that enhances hERG currents by slowing inactivation, promoting activation, reducing inactivation, and shortening atrial and ventricular repolarization in a complex manner.
In vitro
A-935142 (60μM) increases both outward and inward K(+) current as well as the slope conductance of the linear portion of the fully activated I-V relation. A-935142 shortens cardiac action potentials and enhances the amplitude of the hERG current in a concentration- and voltage-dependent manner. A-935142 significantly reduces the time constants (tau) of hERG channel activation at two example voltages and shifts the voltage dependence for hERG activation in the hyperpolarizing direction by 9 mV.[2]
A-935142 shortens the action potential duration (APD90) in guinea pig atrial tissue and canine cardiac Purkinje fibers[1].
Chemical Properties
Molecular Weight352.35
FormulaC18H19F3N2O2
Cas No.1031335-85-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 5.63 mg/mL (15.96 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.8381 mL14.1904 mL28.3809 mL141.9044 mL
5 mM0.5676 mL2.8381 mL5.6762 mL28.3809 mL
10 mM0.2838 mL1.4190 mL2.8381 mL14.1904 mL

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