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AACOCF3
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid and a potent, selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Additionally, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets, making it promising for cardiovascular disease research.
Catalog No. T21681Cas No. 149301-79-1
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Concentration:10.0 mg/mL
Purity:99%
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AACOCF3
Catalog No. T21681Alias Arachidonyltrifluoromethane, Arachidonyl trifluoromethyl ketoneCas No. 149301-79-1
AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid and a potent, selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Additionally, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets, making it promising for cardiovascular disease research.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg（28.05 mM * 100 μL in Ethanol） | $70 | Inquiry | |
| 5 mg（28.05 mM * 500 μL in Ethanol） | $148 | Inquiry |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | AACOCF3 (Arachidonyl trifluoromethyl ketone) is a cell-permeable trifluoromethyl ketone analog of arachidonic acid and a potent, selective slow binding inhibitor of the 85-kDa cytosolic phospholipase A2 (cPLA2). By blocking the production of arachidonate and 12-hydroxyeicosatetraenoic acid in calcium ionophore-challenged platelets, AACOCF3 hinders their synthesis. Additionally, AACOCF3 inhibits glucose-induced insulin secretion from isolated rat islets, making it promising for cardiovascular disease research. |
| In vitro | AACOCF3 inhibits the release of arachidonic acid from calcium ionophore-challenged U937 cells with an IC50 of 8 μM and from platelets with an IC50 of 2 μM[1]. At 10 μM, AACOCF3 suppresses phosphate-induced calcification and osteogenic/chondrogenic signaling in HAoSMCs. It also significantly inhibits both basal and Pi-induced release of arachidonic acid, a product of PLA2 activity[2]. |
| In vivo | 'AACOCF3 (10 mg/kg; gavage; 5 days a week; ApoE–/– mice (6-week-old males) on a high-cholesterol diet) significantly reduces type III collagen plaque expression, without affecting total collagen accumulation[3].' |
| Alias | Arachidonyltrifluoromethane, Arachidonyl trifluoromethyl ketone |
| Molecular Weight | 356.47 |
| Formula | C21H31F3O |
| Cas No. | 149301-79-1 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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