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AR 231453

Catalog No. T8329 CAS 733750-99-7

AR 231453 is a selective and orally available GPR119 agonist,can stimulate β-cell replication and improve islet graft function.

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AR 231453, CAS 733750-99-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 33.00
2 mg	In stock	$ 47.00
5 mg	In stock	$ 63.00
10 mg	In stock	$ 97.00
25 mg	In stock	$ 175.00
50 mg	In stock	$ 261.00
100 mg	In stock	$ 393.00
1 mL * 10 mM (in DMSO)	In stock	$ 85.00

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Purity: 99.45%

Purity: 99.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

AR 231453 is a selective and orally available GPR119 agonist,can stimulate β-cell replication and improve islet graft function.

Molecular Weight	505.52
Formula	C21H24FN7O5S
CAS No.	733750-99-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/mL (118.69 mM)

H2O: 60 mg/mL (118.69 mM), Sonication and heating are recommended.

References and Literature

1. Chu ZL, et al. A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic control by enhancing glucagon-like Peptide-1 and glucose-dependent insulinotropic Peptide release. Endocrinology. 2008 May;149(5):2038-47. 2. Semple G, et al. Discovery of the first potent and orally efficacious agonist of the orphan G-protein coupled receptor 119. J Med Chem. 2008 Sep 11;51(17):5172-5.

Related compound libraries

This product is contained In the following compound libraries：

GPCR Compound Library Orally Active Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Endocrinology-Hormone Compound Library NO PAINS Compound Library Bioactive Compounds Library Max Anti-Diabetic Compound Library

Related Products

Related compounds with same targets

MS21570 BigLEN (mouse) acetate Monomethyl fumarate CRTh2 antagonist 2 (1S,2R)-2-PCCA LY2922470 AM251 GW9508

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

AR 231453 733750-99-7 Endocrinology/Hormones GPCR/G Protein GPR inhibit GPR119 G Protein-Coupled Receptor 119 diabetes AR231453 insulin Inhibitor HIT-T15 AR-231453 glucose GPCR inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.