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ARRY-380 (analog )

Catalog No. T2518 CAS 937265-83-3

Synonyms: ARRY380, ARRY-380 analog, HER2-Inhibitor-1

ARRY-380 is a potent and selective HER2 inhibitor.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

ARRY-380 (analog ), CAS 937265-83-3

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	ARRY-380 is a potent and selective HER2 inhibitor.
Targets&IC50	HER2:8 nM
Kinase Assay	The Millipore Kinase Profiler service is used to generate general selectivity data for SCH 900776 against a broad range of serine/threonine and tyrosine kinases. Assays are typically run at two concentrations of SCH 900776 (0.5 and 5 μM), at a fixed (10 μM) concentration of ATP. Data are provided as percent activity remaining, relative to uninhibited controls.

Synonyms	ARRY380, ARRY-380 analog, HER2-Inhibitor-1
Molecular Weight	569.64
Formula	C29H27N7O4S
CAS No.	937265-83-3

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 91 mg/mL(159.8 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Madala SK, et al. Am J Respir Cell Mol Biol. 2012 Mar;46(3):380-8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Lung Cancer Compound Library Cytokine Inhibitor Library Immuno-Oncology Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets

Neolinine 4-Hydroxycinnamamide Ligustroside Panitumumab Unecritinib EMI1 Brivanib BMS-599626

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

ARRY-380 (analog ) 937265-83-3 JAK/STAT信号通路蛋白酪氨酸激酶血管生成 EGFR HER Inhibitor HER1 ARRY380 (analog ) Epidermal growth factor receptor ARRY 380 (analog ) analog ATP-competitive HER2-Inhibitor-1 ARRY-380 ARRY-380 analog ErbB-1 ARRY 380 ARRY380 inhibit inhibitor

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