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ARRY-380 (analog )

Catalog No. T2518   CAS 937265-83-3
Synonyms: ARRY380, ARRY-380 analog, HER2-Inhibitor-1

ARRY-380 is a potent and selective HER2 inhibitor.

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ARRY-380 (analog ), CAS 937265-83-3
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description ARRY-380 is a potent and selective HER2 inhibitor.
Targets&IC50 HER2:8 nM
Kinase Assay The Millipore Kinase Profiler service is used to generate general selectivity data for SCH 900776 against a broad range of serine/threonine and tyrosine kinases. Assays are typically run at two concentrations of SCH 900776 (0.5 and 5 μM), at a fixed (10 μM) concentration of ATP. Data are provided as percent activity remaining, relative to uninhibited controls.
Synonyms ARRY380, ARRY-380 analog, HER2-Inhibitor-1
Molecular Weight 569.64
Formula C29H27N7O4S
CAS No. 937265-83-3


Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 91 mg/mL(159.8 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Madala SK, et al. Am J Respir Cell Mol Biol. 2012 Mar;46(3):380-8.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Lung Cancer Compound Library Cytokine Inhibitor Library Immuno-Oncology Compound Library Anti-Breast Cancer Compound Library

Related Products

Related compounds with same targets
Neolinine 4-Hydroxycinnamamide Ligustroside Panitumumab Unecritinib EMI1 Brivanib BMS-599626

Dose Conversion

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Molarity Calculator
Dilution Calculator
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Molecular Weight Calculator

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
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An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
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The answer of 19.713 mg appears in the Mass box


Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box


Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.


Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.


ARRY-380 (analog ) 937265-83-3 JAK/STAT信号通路 蛋白酪氨酸激酶 血管生成 EGFR HER Inhibitor HER1 ARRY380 (analog ) Epidermal growth factor receptor ARRY 380 (analog ) analog ATP-competitive HER2-Inhibitor-1 ARRY-380 ARRY-380 analog ErbB-1 ARRY 380 ARRY380 inhibit inhibitor