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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $41 | In Stock |
Description | AZD5582 is an inhibitor of IAPs, which binds to the BIR3 domains cIAP1, cIAP2, and XIAP with IC50s of 15, 21, and 15 nM, respectively. It induces apoptosis. |
Targets&IC50 | CIAP1:15 nM (IC50), XIAP:15 nM (IC50), CIAP2:21 nM (IC50) |
In vitro | AZD5582 (20 nM; 48 hours) inhibited cell viability by cooperating with IFNγ or viral double-stranded RNA (dsRNA) in H1975 NSCLC cells[2]. In HCC827 NSCLC cells, AZD5582 (20 nM; 48 hours) induced apoptosis by activating cell death and caspase-3/-8 through co-treatment with IFNγ[2]. Additionally, AZD5582 (20 nM; 17 or 25 hours) down-regulated cIAP-1, activated RIPK1 (an upstream regulator of caspase-8), and initiated both extrinsic (caspase-8) and intrinsic (caspase-9) apoptosis pathways, leading to the cleavage of caspase-3 and caspase-7[2]. |
In vivo | AZD5582 (intravenous injection; 0.1-3.0 mg/kg; once a week; 2 weeks) induces cIAP1 degradation and caspase 3 cleavage in tumor cells, leading to significant tumor resolution after two weeks. A medium dose (0.5 mg/kg) of AZD5582 degrades cIAP1 but requires additional time to achieve apoptosis-inducing effects[1]. |
Molecular Weight | 1015.29 |
Formula | C58H78N8O8 |
Cas No. | 1258392-53-8 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 66.25 mg/mL (65.25 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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