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Ancriviroc
Catalog No. T30047Cas No. 370893-06-4
Alias Schering C, SCH-351125, CHEMBL336672, AC1NUILE, [3H]ancriviroc
Ancriviroc (SCH-351125) is an oxime-piperidine compound with strong antiretroviral activity and an orally bioavailable small molecule chemokine receptor CCR5 antagonist (Kd value 9.27nM) that enters HIV-1 through the CCR5 co-receptor and is used to study HIV-1.
Ancriviroc
Catalog No. T30047Alias Schering C, SCH-351125, CHEMBL336672, AC1NUILE, [3H]ancrivirocCas No. 370893-06-4
Ancriviroc (SCH-351125) is an oxime-piperidine compound with strong antiretroviral activity and an orally bioavailable small molecule chemokine receptor CCR5 antagonist (Kd value 9.27nM) that enters HIV-1 through the CCR5 co-receptor and is used to study HIV-1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $483 | In Stock | |
| 10 mg | $692 | In Stock | |
| 25 mg | $1,080 | In Stock | |
| 50 mg | $1,490 | In Stock | |
| 100 mg | $1,970 | In Stock |
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Purity:99.74%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Ancriviroc (SCH-351125) is an oxime-piperidine compound with strong antiretroviral activity and an orally bioavailable small molecule chemokine receptor CCR5 antagonist (Kd value 9.27nM) that enters HIV-1 through the CCR5 co-receptor and is used to study HIV-1. |
| In vitro | METHODS: Chinese hamster ovary (CHO) cell membranes expressing human CCR5 were incubated with Ancriviroc (SCH-351125) (10-0.3 nM), and Ki values were calculated using GRAPHPAD PRISM software based on experimentally determined IC50 and KD values. RESULTS Ancriviroc (SCH-351125) inhibited the binding of RANTES to CHO cell membranes expressing human CCR5 in a dose-dependent manner with a Ki value of 2.9 nM; Ancriviroc (SCH-351125) bound to CCR5 with high affinity with a KD of 9.27 nM. [1] |
| In vivo | METHODS: In a SCID-mouse model treated with (SCH-351125) (30 mg/kg, orally, daily), HLA-ABC levels on implanted cells from treated and untreated mice were measured by FACS analysis using mAb W6/32. RESULTS SCH-C had potent and dose-dependent antiviral activity in the SCID-mouse model; MHC class I expression on implanted cells from (SCH-351125)-treated mice was reduced in a dose-dependent manner, further confirming the inhibition of viral replication by SCH-C. [1] |
| Alias | Schering C, SCH-351125, CHEMBL336672, AC1NUILE, [3H]ancriviroc |
| Molecular Weight | 557.52 |
| Formula | C28H37BrN4O3 |
| Cas No. | 370893-06-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (89.68 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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