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Aviptadil Acetate

Catalog No. TP1016L CAS 1444827-29-5

Synonyms: Vasoactive Intestinal Peptide acetate salt

Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for research on pulmonary fibrosis, pulmonary hypertension (PAH), and respiratory failure caused by SARS-CoV-2.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Aviptadil Acetate, CAS 1444827-29-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 84.00
5 mg	In stock	$ 178.00
10 mg	In stock	$ 289.00
25 mg	In stock	$ 489.00
50 mg	In stock	$ 686.00
100 mg	In stock	$ 969.00

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Purity: 100%

Biological Description

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Description	Aviptadil Acetate (Vasoactive Intestinal Peptide acetate salt) induces pulmonary vasodilation and inhibits the proliferation of vascular SMCs and platelet aggregation. Avitadil acetate can be used for research on pulmonary fibrosis, pulmonary hypertension (PAH), and respiratory failure caused by SARS-CoV-2.
In vitro	Aviptadil acetate inhibits the basal proliferation of pulmonary arterial smooth muscle cells (PASMC) and the mobilization of intracellular free calcium concentration in these cells in a dose-dependent manner[2].
In vivo	Inhaled vasoactive intestinal peptide(Aviptadil acetate ) as a local therapy to reduce the alveolar inflammation found in patients with immune checkpoint inhibitor pneumonitis[1].

Synonyms	Vasoactive Intestinal Peptide acetate salt
Molecular Weight	3385.9
Formula	C147H238N44O42S.C2H4O2
CAS No.	1444827-29-5

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 95mg/mL (28.06 mM)

References and Literature

1. Frye BC, Meiss F, von Bubnoff D, Zissel G, Müller-Quernheim J. Vasoactive Intestinal Peptide in Checkpoint Inhibitor-Induced Pneumonitis. N Engl J Med. 2020;382(26):2573-2574. doi:10.1056/NEJMc2000343 2. Hu J , Xu Q , Mctiernan C , et al. Novel Targets of Drug Treatment for Pulmonary Hypertension[J]. American Journal of Cardiovascular Drugs, 2015, 15(4):225-234.

Related compound libraries

This product is contained In the following compound libraries：

Peptide Compound Library Anti-Viral Compound Library FDA-Approved & Pharmacopeia Drug Library Endocrinology-Hormone Compound Library Anti-Hypertension Compound Library Anti-Infection Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Aviptadil Acetate 1444827-29-5 Endocrinology/Hormones Microbiology/Virology SARS-CoV RAAS Vasoactive Intestinal Peptide acetate salt (human, rat, mouse, rabbit, canine, porcine) SARS coronavirus ALI Respiratory Failure Pulmonary Fibrosis Corona Virus Lung Injury ARDS inhibit Sarcoid Aviptadil Respiratory Distress Syndrome Inhibitor Vasoactive Intestinal Peptide Acetate Sarcoidosis Bronchospasm Vasoactive Intestinal Peptide acetate salt inhibitor

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