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BMS CCR2 22

Catalog No. T14688   CAS 445479-97-0

BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.

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BMS CCR2 22 Chemical Structure
BMS CCR2 22, CAS 445479-97-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 297.00
10 mg In stock $ 419.00
25 mg In stock $ 647.00
50 mg In stock $ 987.00
100 mg In stock $ 1,330.00
500 mg In stock $ 2,670.00
1 mL * 10 mM (in DMSO) In stock $ 388.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.
Targets&IC50 CCR2:5.1 nM
In vitro BMS CCR2 22 inhibits the internalization of hMCP1_AF647 (IC50 = 2 nM)[2]. HAoECs with BMS CCR2 22 before MCP-1 increases the cell surface levels of VCAM-1 from 72.8 to 160% and PECAM1 from 97.2 and 127%[3].
Molecular Weight 593.66
Formula C28H34F3N5O4S
CAS No. 445479-97-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225.0 mg/mL (379.0 mM), sonification is recommended.

TargetMolReferences and Literature

1. Cherney RJ, et al. Discovery of disubstituted cyclohexanes as a new class of CC chemokine receptor 2 antagonists. J Med Chem. 2008 Feb 28;51(4):721-4. 2. Kredel S, et al. High-content analysis of CCR2 antagonists on human primary monocytes. J Biomol Screen. 2011 Aug;16(7):683-93. 3. D'Antoni ML, et al. Cenicriviroc inhibits trans-endothelial passage of monocytes and is associated with impaired E-selectin expression. J Leukoc Biol. 2018 Dec;104(6):1241-1252.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Bioactive Compounds Library Max Covalent Inhibitor Library Inhibitor Library

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Keywords

BMS CCR2 22 445479-97-0 Immunology/Inflammation Microbiology/Virology CCR BMS CCR-2 22 inhibitor inhibit

 

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