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BMS CCR2 22

BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.

Catalog No. T14688Cas No. 445479-97-0

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BMS CCR2 22

Catalog No. T14688Cas No. 445479-97-0

BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.

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Pack Size	Price	Availability
1 mg	$53	In Stock
5 mg	$118	In Stock
10 mg	$193	In Stock
25 mg	$387	In Stock
50 mg	$592	In Stock
100 mg	$798	In Stock
200 mg	$1,070	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock

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Product Introduction

Bioactivity

Description	BMS CCR2 22 is a potent and selective antagonist of CCR2 with calcium flux IC50 of 18 nM, chemotaxis IC50 of 1 nM, and binding IC50 of 5.1 nM.
Targets&IC50	CCR2:5.1 nM
In vitro	BMS CCR2 22 inhibits the internalization of hMCP1_AF647 (IC50 = 2 nM)[2]. HAoECs with BMS CCR2 22 before MCP-1 increases the cell surface levels of VCAM-1 from 72.8 to 160% and PECAM1 from 97.2 and 127%[3].

Chemical Properties

Molecular Weight	593.66
Formula	C₂₈H₃₄F₃N₅O₄S
Cas No.	445479-97-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 225.0 mg/mL (379.0 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6845 mL	8.4223 mL	16.8447 mL	84.2233 mL
5 mM	0.3369 mL	1.6845 mL	3.3689 mL	16.8447 mL
10 mM	0.1684 mL	0.8422 mL	1.6845 mL	8.4223 mL
20 mM	0.0842 mL	0.4211 mL	0.8422 mL	4.2112 mL
50 mM	0.0337 mL	0.1684 mL	0.3369 mL	1.6845 mL
100 mM	0.0168 mL	0.0842 mL	0.1684 mL	0.8422 mL

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In Vivo Formulation Calculator (Clear solution)

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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