Home Tools
Log in
Cart

BMS-191011

Catalog No. T7512   CAS 202821-81-6
Synonyms: BMS-A

BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
BMS-191011 Chemical Structure
BMS-191011, CAS 202821-81-6
Pack Size Availability Price/USD Quantity
5 mg In stock $ 51.00
10 mg In stock $ 79.00
25 mg In stock $ 163.00
50 mg In stock $ 308.00
100 mg In stock $ 463.00
1 mL * 10 mM (in DMSO) In stock $ 58.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 98%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description BMS-191011 (BMS-A) is an activator of large-conductance calcium-activated potassium (BKCa) channels ,effective in stroke models
In vivo In vivo, BMS 191011 (10-100 μg/kg, i.v.) increases the diameter of retinal arterioles without affecting blood pressure or heart rate in rats, an effect that is reversed by the BKCa channel blocker iberiotoxin[1]
Synonyms BMS-A
Molecular Weight 370.71
Formula C16H10ClF3N2O3
CAS No. 202821-81-6

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (337.19 mM)

TargetMolReferences and Literature

1. Mori A , Suzuki S , Sakamoto K , et al. BMS-191011, an Opener of Large-Conductance Ca2+-Activated Potassium Channels, Dilates Rat Retinal Arterioles in Vivo[J]. Biological & Pharmaceutical Bulletin, 2011, 34(1):150-152. 2. Hewawasam P . Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.[J]. Bioorganic & Medicinal Chemistry Letters, 2003, 13(10):1695-1698.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compound Library Target-Focused Phenotypic Screening Library Ion Channel Inhibitor Library Bioactive Compounds Library Max Potassium Channel Blocker Library Anti-Cancer Compound Library

Related Products

Related compounds with same targets
Cisapride Nicorandil BmP02 ML277 2,2,2-Trichloroethanol Clofilium tosylate DCPIB NS3623

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-191011 202821-81-6 Membrane transporter/Ion channel Potassium Channel rodent models of stroke Panc-1 neuroprotective activity inhibit IGR39 Inhibitor BMS 191011 BMS-A BMS191011 KcsA inhibitor

 

TargetMol