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BMS-345541 hydrochloride

Catalog No. T8542 CAS 547757-23-3

BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).

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BMS-345541 hydrochloride Chemical Structure

BMS-345541 hydrochloride, CAS 547757-23-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 79.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 236.00
50 mg	In stock	$ 396.00
100 mg	In stock	$ 593.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.92%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	BMS-345541 hydrochloride is a selective IKK inhibitor (IKK2 and IKK1 with IC50 of 0.3 μM and 4 μM,respectively).
Targets&IC50	IKK1:4 μM, IKK2:0.3 μM
In vitro	BMS-345541 down-regulation of IKK activity results in mitochondria-mediated apoptosis of tumor cells because the programmed cell death machinery in melanoma cells is highly regulated by NF-kappaB signaling. Therefore, IKK may serve as a potential target for melanoma therapy[1].

Molecular Weight	291.78
Formula	C14H18ClN5
CAS No.	547757-23-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 18 mg/mL (61.69 mM), Sonification is recommended.

References and Literature

1. Yang J, et al. BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin Cancer Res, 2006, 12(3 Pt 1), 950-960. 2. MacMaster JF, et al. An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. Inflamm Res, 2003, 52(12), 508-511. 3. Burke JR, et al. BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. J Biol Chem, 2003, 278(3), 1450-1456.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Anti-Breast Cancer Compound Library Kinase Inhibitor Library Anti-Ovarian Cancer Compound Library Bioactive Compound Library Anti-Prostate Cancer Compound Library NF-κB Signaling Compound Library NO PAINS Compound Library Immunology/Inflammation Compound Library Anti-Cancer Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-345541 hydrochloride 547757-23-3 NF-Κb IκB/IKK I kappa B kinase BMS 345541 Hydrochloride BMS345541 hydrochloride Inhibitor BMS345541 BMS-345541 BMS 345541 IKK IκB kinase BMS345541 Hydrochloride BMS 345541 hydrochloride BMS-345541 Hydrochloride inhibit inhibitor

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