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BOT-64

Catalog No. T8705   CAS 113760-29-5

BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound

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BOT-64 Chemical Structure
BOT-64, CAS 113760-29-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 80.00
5 mg In stock $ 197.00
10 mg In stock $ 313.00
25 mg In stock $ 597.00
50 mg In stock $ 913.00
100 mg In stock $ 1,230.00
1 mL * 10 mM (in DMSO) In stock $ 182.00
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Purity: 98.08%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound
In vitro BOT-64 inhibits IKKbeta-mediated IkappaBalpha phosphorylation in LPS-activated macrophages, resulting in sequential prevention of downstream events, including proteolytic degradation of IkappaBalpha, DNA binding ability, and transcriptional activity of NF-kappaB.?BOT-64 inhibits LPS-inducible IKKbeta activity in the cells and catalytic activity of highly purified IKKbeta.?Moreover, the effect of BOT-64 on cell-free IKKbeta was abolished by substitution of Ser-177 and Ser-181 residues in the activation loop of IKKbeta to glutamic acid residues, indicating a direct interaction site of benzoxathiole.?BOT-64 attenuates NF-kappaB-regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in LPS-activated or expression vector IKKbeta-transfected macrophages.
Molecular Weight 273.35
Formula C15H15NO2S
CAS No. 113760-29-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (109.75 mM)

TargetMolReferences and Literature

1. Kim B H , Roh E , Lee H Y , et al. Benzoxathiole derivative blocks lipopolysaccharide-induced nuclear factor-kappaB activation and nuclear factor-kappaB-regulated gene transcription through inactivating inhibitory kappaB kinase beta.[J]. Molecular Pharmacology, 2008, 73(4):1309-1318.

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Bioactive Compound Library Kinase Inhibitor Library Inhibitor Library Anti-Liver Cancer Compound Library Pyroptosis Compound Library Anti-Prostate Cancer Compound Library NO PAINS Compound Library Covalent Inhibitor Library Anti-Breast Cancer Compound Library

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Keywords

BOT-64 113760-29-5 NF-Κb IκB/IKK IL-6 I kappa B kinase inhibit inflammatory BOT64 NF-κb RAW 264.7 IKK IκB kinase Inhibitor BOT 64 inhibitor

 

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