Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 80.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 313.00 | |
25 mg | In stock | $ 597.00 | |
50 mg | In stock | $ 913.00 | |
100 mg | In stock | $ 1,230.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 182.00 |
Description | BOT-64 is an IKK-2 inhibitor which targets the Ser177 and/or Ser181 residues in the kinase's activation loop domain.BOT-64 is a cell-permeable benzoxathiole compound |
In vitro | BOT-64 inhibits IKKbeta-mediated IkappaBalpha phosphorylation in LPS-activated macrophages, resulting in sequential prevention of downstream events, including proteolytic degradation of IkappaBalpha, DNA binding ability, and transcriptional activity of NF-kappaB.?BOT-64 inhibits LPS-inducible IKKbeta activity in the cells and catalytic activity of highly purified IKKbeta.?Moreover, the effect of BOT-64 on cell-free IKKbeta was abolished by substitution of Ser-177 and Ser-181 residues in the activation loop of IKKbeta to glutamic acid residues, indicating a direct interaction site of benzoxathiole.?BOT-64 attenuates NF-kappaB-regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-6 in LPS-activated or expression vector IKKbeta-transfected macrophages. |
Molecular Weight | 273.35 |
Formula | C15H15NO2S |
CAS No. | 113760-29-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (109.75 mM)
You can also refer to dose conversion for different animals. More
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BOT-64 113760-29-5 NF-Κb IκB/IKK IL-6 I kappa B kinase inhibit inflammatory BOT64 NF-κb RAW 264.7 IKK IκB kinase Inhibitor BOT 64 inhibitor