Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BRD0209 is a highly selective and potent GSK3 inhibitor.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 98.00 | |
5 mg | In stock | $ 247.00 | |
10 mg | In stock | $ 372.00 | |
25 mg | In stock | $ 629.00 | |
50 mg | In stock | $ 896.00 | |
100 mg | In stock | $ 1,220.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 261.00 |
Description | BRD0209 is a highly selective and potent GSK3 inhibitor. |
Targets&IC50 | GSK-3β:5 nM, GSK-3α:19 nM |
In vitro | BRD0209 showed concentration-dependent inhibition of Tau with cellular EC50s of 1.76 μM, respectively, in SH-SY5Y cells using ELISA. Treatment of SH-SY5Y cells with BRD0209 (10 μM) significantly inhibited GSK3 kinase activity within 30 min, as seen in the decrease in phospho-CRMP2 and phospho-β-catenin. BRD0209 is also a reversible ATP-competitive inhibitor with fast-off kinetics (Ki = 4.2 nM, respectively).BRD0209 treatment caused a dramatic decrease in autophosphorylation at Tyr279 (pGSK3α) and Tyr216 (pGSK3β) with longer exposure (24 h) [1]. |
Synonyms | BRD-0209, BRD 0209 |
Molecular Weight | 347.45 |
Formula | C22H25N3O |
CAS No. | 1597439-87-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 3.47 mg/mL (10 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
BRD0209 1597439-87-6 PI3K/Akt/mTOR signaling Stem Cells GSK-3 BRD-0209 BRD 0209 inhibitor inhibit