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BRD0639

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Purity:99.46%

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COA HNMR HPLC

BRD0639

Catalog No. T9329Cas No. 2760881-74-9

BRD0639 is a pioneering inhibitor targeting the interaction between PRMT5 and its substrate adaptor. As a competitive inhibitor of the PRMT5 binding motif (PBM), BRD0639 facilitates the investigation of activities dependent on PBM-associated PRMT5 functions [1].

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Pack Size	Price	Availability
1 mg	$51	In Stock
5 mg	$122	In Stock
10 mg	$198	In Stock
25 mg	$413	In Stock
50 mg	$563	In Stock
100 mg	$788	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

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Product Introduction

Bioactivity

Description

In vitro

BRD0639, a pioneering PBM-competitive small molecule, facilitates the research of PBM-dependent PRMT5 activities and aids in developing specific PRMT5 inhibitors. It effectively binds to the cellular target, efficiently inhibiting the interaction between full-length PRMT5 and RIOK1 proteins with IC50 values of 7.5 uM and 16 uM in permeabilized and living cells, respectively. Moreover, BRD0639 decreases SDMA levels in proteins impacted by genetic alterations of the PRMT5 binding motif (PBM) site [1].

Chemical Properties

Molecular Weight	475.95
Formula	C21H22ClN5O4S
Cas No.	2760881-74-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 60 mg/ml (126.06 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1011 mL	10.5053 mL	21.0106 mL	105.0531 mL
5 mM	0.4202 mL	2.1011 mL	4.2021 mL	21.0106 mL
10 mM	0.2101 mL	1.0505 mL	2.1011 mL	10.5053 mL
20 mM	0.1051 mL	0.5253 mL	1.0505 mL	5.2527 mL
50 mM	0.0420 mL	0.2101 mL	0.4202 mL	2.1011 mL
100 mM	0.0210 mL	0.1051 mL	0.2101 mL	1.0505 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc