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BRD7552

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.

Catalog No. T6793Cas No. 1137359-47-7

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Purity:98%

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COA LCMS HNMR

BRD7552

Catalog No. T6793Cas No. 1137359-47-7

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.

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Pack Size	Price	Availability
1 mg	$34	In Stock
2 mg	$48	In Stock
5 mg	$77	In Stock
10 mg	$97	In Stock
25 mg	$223	In Stock
50 mg	$433	In Stock
1 mL x 10 mM (in DMSO)	$122	In Stock

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Product Introduction

Bioactivity

Description

BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.

In vitro

BRD7552 upregulates PDX1 expression in both primary human islets and ductal cells, and induces epigenetic changes in the PDX1 promoter consistent with transcriptional activation. BRD7552 increases PDX1 mRNA levels by 2- to 4-fold, with a maximal effect at 5 μM and the expression of MAFA. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. Treatment of PANC-1 cells with BRD7552 causes a dose-dependent increase in insulin mRNA expression. [1]

Chemical Properties

Molecular Weight	711.63
Formula	C₃₃H₃₃N₃O₁₅
Cas No.	1137359-47-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 93 mg/mL (130.7 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 93 mg/mL (130.7 mM)

Solution Preparation Table

DMSO/Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.4052 mL	7.0261 mL	14.0522 mL	70.2612 mL
5 mM	0.2810 mL	1.4052 mL	2.8104 mL	14.0522 mL
10 mM	0.1405 mL	0.7026 mL	1.4052 mL	7.0261 mL
20 mM	0.0703 mL	0.3513 mL	0.7026 mL	3.5131 mL
50 mM	0.0281 mL	0.1405 mL	0.2810 mL	1.4052 mL
100 mM	0.0141 mL	0.0703 mL	0.1405 mL	0.7026 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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Keywords

promoterBRD7552isletsBRD-7552humaninhibitepigeneticductalchangesBRD 7552insulinprimaryInhibitorcells