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Search Results for " ductal "

Targets

23

Compounds

1

Natural Products

21

Recombinant Proteins

1

Libraries

Cat No. Product Name Synonyms Targets
T4367 Mycro 3 Mycro-3 c-Myc , Autophagy
Mycro 3 is potent and selective for c-Myc in whole cell assays.
T6793 BRD7552 Others
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells.
T8766 GOT1 inhibitor-1 GOT1 inhibitor 2c Others
GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM.
T2613 Almorexant ACT 078573 OX Receptor
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
T6155 Almorexant hydrochloride ACT-078573 hydrochloride,Almorexant HCl OX Receptor
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively.
T77522 BCAT-IN-4 Others
BCAT-IN-4 is a potent BCAT inhibitor with an IC50 value of 2.35 μM for hBCATc. BCAT-IN-4 has anticancer activity and can be used to study pancreatic ductal adenocarcinoma.
T76873 Nidanilimab CAN04 IL Receptor
Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β signaling pathways and inducing the immune system to destr...
T60202 MMRi62 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol Ferroptosis
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity aga...
T13161 Tin-protoporphyrin IX SnPPIX Others
Tin-protoporphyrin IX is a potent inhibitor of Heme oxygenase-1 (HO-1). It sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice models.
T24693 QD325 QD 325,QD-325
QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in the nucleus, endoplasmic reticulum...
T69106 Avarol
Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheim...
TP1047 Secretin, porcine TFA (17034-34-3 free base) Porcine secretin TFA,Secretin, porcine TFA
Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.Secretin porcine stimulates panc...
T70646 Deltarasin HCl
Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/...
T62748 Nampt-IN-9
Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas.
T70223 UA8967
UA8967 is a membrane-active anti-tumor agent. Cytotoxicity studies in six pancreatic cancer cell lines, one normal human pancreatic ductal epithelial line and two colon cancer cells showed the IC50s UA8967 ranged from 12...
TP1048 Secretin, porcine Porcine secretin acetate
Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid. Secretin porcine stimulates pan...
T75973 Secretin, porcine TFA
Secretin, Porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide that targets pancreatic acinar and ductal epithelial cells, inducing the secretion of bicarbonate-rich fluid [1].
T82673 CPF-7 Caerulein precursor fragment
CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulation in PANC-1 ductal cells. Moreover, it induces exocrine plasti...
T79689 SIRT6-IN-3 Sirtuin
SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to ...
T72355 KRAS G12D inhibitor 16
KRAS G12D Inhibitor 16 is a potent compound targeting the KRAS G12D and its mutation, exhibiting inhibitory activity with IC50 values of 0.7 nM and 0.35 μM, respectively. It is utilized in researching various malignant t...
T63902 XP-524
XP-524 is a potent inhibitor of BET and EP300. XP-524 has significant tumouricidal effects in vivo, preventing KRAS-induced tumour transformation in vivo and prolonging survival in two aggressive PDAC transgenic mouse mo...
T83880 C18 Ceramide-1-phosphate (d18:1/18:0) ammonium Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate
C18 Ceramide-1-phosphate (d18:1/18:0) is a long-chain molecule identified in murine skin known to promote the migration of mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells (H...
T36103 TW9 TW9
TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μ...
Cat No. Product Name Synonyms Targets
T36179 Aspulvinone O
Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulv...

Recombinant Proteins

Cat No. Product Name Species Expression System
TMPY-02154 FAP Protein, Human, Recombinant (His) Human HEK293
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S...
TMPY-04962 FAP Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S...
TMPY-04922 FAP Protein, Human, Recombinant (His), Biotinylated Human HEK293
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S...
TMPK-00721 CX3CL1/Fractalkine Protein, Mouse, Recombinant (His & Avi), Biotinylated Mouse HEK293
Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer...
TMPY-00585 Annexin A8 Protein, Human, Recombinant (His) Human E. coli
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA...
TMPY-01346 Psoriasin/S100A7 Protein, Human, Recombinant Human E. coli
Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can b...
TMPH-00228 BMP-4 Protein, Bovine, Recombinant (GST) Bovine E. coli
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimu...
TMPH-01017 BMP-4 Protein, Human, Recombinant (His) Human E. coli
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimu...
TMPY-02497 S100A15 Protein, Mouse, Recombinant (His & MBP) Mouse E. coli
Koebnerisin is also known as protein S100-A7A (S100A7A), S100 calcium-binding protein A7-like 1 (S100A7L1) or S100 calcium-binding protein A15 (S100A15). Human S100A7A / S100A15 is a novel member of the S100 family of EF...
TMPY-03571 TROY Protein, Human, Recombinant (His) Human HEK293
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc...
TMPY-03194 TROY Protein, Human, Recombinant (hFc) Human HEK293
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc...
TMPY-04075 CLIC1 Protein, Human, Recombinant (His) Human E. coli
Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. Chloride intracellular channel 1 (C...
TMPY-01388 TROY Protein, Mouse, Recombinant (His) Mouse HEK293
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc...
TMPY-05792 TROY Protein, Mouse, Recombinant (mFc) Mouse HEK293
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc...
TMPY-01335 REG1A Protein, Human, Recombinant (His) Human HEK293
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa...
TMPY-03684 REG1A Protein, Cynomolgus, Recombinant (hFc) Cynomolgus HEK293
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa...
TMPY-03092 REG1A Protein, Rat, Recombinant (hFc) Rat HEK293
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa...
TMPY-05474 REG1A Protein, Human, Recombinant (His), Biotinylated Human HEK293
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa...
TMPY-03639 REG1A Protein, Cynomolgus, Recombinant (His) Cynomolgus HEK293
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa...
TMPY-06525 FAP Protein, Human, Recombinant (aa 27-760, His) Human Baculovirus-Insect Cells
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S...
TMPY-06915 FAP Protein, Human, Recombinant (His & Avi), Biotinylated Human HEK293
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S...
FAP Protein, Human, Recombinant (His)
TMPY-02154
Species: Human
Expression System: HEK293
FAP Protein, Cynomolgus, Recombinant (His)
TMPY-04962
Species: Cynomolgus
Expression System: HEK293
FAP Protein, Human, Recombinant (His), Biotinylated
TMPY-04922
Species: Human
Expression System: HEK293
CX3CL1/Fractalkine Protein, Mouse, Recombinant (His & Avi), Biotinylated
TMPK-00721
Species: Mouse
Expression System: HEK293
Annexin A8 Protein, Human, Recombinant (His)
TMPY-00585
Species: Human
Expression System: E. coli
Psoriasin/S100A7 Protein, Human, Recombinant
TMPY-01346
Species: Human
Expression System: E. coli
BMP-4 Protein, Bovine, Recombinant (GST)
TMPH-00228
Species: Bovine
Expression System: E. coli
BMP-4 Protein, Human, Recombinant (His)
TMPH-01017
Species: Human
Expression System: E. coli
S100A15 Protein, Mouse, Recombinant (His & MBP)
TMPY-02497
Species: Mouse
Expression System: E. coli
TROY Protein, Human, Recombinant (His)
TMPY-03571
Species: Human
Expression System: HEK293
TROY Protein, Human, Recombinant (hFc)
TMPY-03194
Species: Human
Expression System: HEK293
CLIC1 Protein, Human, Recombinant (His)
TMPY-04075
Species: Human
Expression System: E. coli
TROY Protein, Mouse, Recombinant (His)
TMPY-01388
Species: Mouse
Expression System: HEK293
TROY Protein, Mouse, Recombinant (mFc)
TMPY-05792
Species: Mouse
Expression System: HEK293
REG1A Protein, Human, Recombinant (His)
TMPY-01335
Species: Human
Expression System: HEK293
REG1A Protein, Cynomolgus, Recombinant (hFc)
TMPY-03684
Species: Cynomolgus
Expression System: HEK293
REG1A Protein, Rat, Recombinant (hFc)
TMPY-03092
Species: Rat
Expression System: HEK293
REG1A Protein, Human, Recombinant (His), Biotinylated
TMPY-05474
Species: Human
Expression System: HEK293
REG1A Protein, Cynomolgus, Recombinant (His)
TMPY-03639
Species: Cynomolgus
Expression System: HEK293
FAP Protein, Human, Recombinant (aa 27-760, His)
TMPY-06525
Species: Human
Expression System: Baculovirus-Insect Cells
FAP Protein, Human, Recombinant (His & Avi), Biotinylated
TMPY-06915
Species: Human
Expression System: HEK293
Cat No. Product Name
L2191 Anti-Breast Cancer Compound Library

1939 compounds
A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study;
TargetMol