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Cat No. | Product Name | Synonyms | Targets |
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T4367 | Mycro 3 | Mycro-3 | c-Myc , Autophagy |
Mycro 3 is potent and selective for c-Myc in whole cell assays. | |||
T6793 | BRD7552 | Others | |
BRD7552 is an inducer of transcription factor PDX1, which increases insulin expression. BRD7552 increases PDX1 expression in mouse αTC cells but not βTC cells. | |||
T8766 | GOT1 inhibitor-1 | GOT1 inhibitor 2c | Others |
GOT1 inhibitor-1 (GOT1 inhibitor 2c) is a novel, potent and non-covalent inhibitor of glutamate oxaloacetate transaminase 1 (GOT1) with an IC50 of 8.2 uM. | |||
T2613 | Almorexant | ACT 078573 | OX Receptor |
Almorexant (ACT 078573) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T6155 | Almorexant hydrochloride | ACT-078573 hydrochloride,Almorexant HCl | OX Receptor |
Almorexant hydrochloride (ACT-078573 hydrochloride) is a potent and competitive dual orexin 1 receptor (OX1)/orexin 2 receptor (OX2) antagonist with Ki values of 1.3 and 0.17 nM for OX1 and OX2, respectively. | |||
T77522 | BCAT-IN-4 | Others | |
BCAT-IN-4 is a potent BCAT inhibitor with an IC50 value of 2.35 μM for hBCATc. BCAT-IN-4 has anticancer activity and can be used to study pancreatic ductal adenocarcinoma. | |||
T76873 | Nidanilimab | CAN04 | IL Receptor |
Nidanilimab (CAN04) is a fully humanized IL1RAP monoclonal antibody with a Kd value of 1.10 pM. Nidanilimab has antitumor activity, cutting off the IL1α and IL1β signaling pathways and inducing the immune system to destr... | |||
T60202 | MMRi62 | 7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol | Ferroptosis |
MMRi62 (7-[(2,3-dichlorophenyl)-(pyridin-2-ylamino)methyl]quinolin-8-ol), a ferroptosis inducer targeting MDM2-MDM4 (negative regulators of tumor suppressor p53). MMRi62 shows a P53-independent pro-apoptotic activity aga... | |||
T13161 | Tin-protoporphyrin IX | SnPPIX | Others |
Tin-protoporphyrin IX is a potent inhibitor of Heme oxygenase-1 (HO-1). It sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice models. | |||
T24693 | QD325 | QD 325,QD-325 | |
QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in the nucleus, endoplasmic reticulum... | |||
T69106 | Avarol | ||
Avarol induces apoptosis in pancreatic ductal adenocarcinoma cells by activating PERK-eIF2α-CHOP signaling. Avarl also acts as a competitive AChE inhibitor which are non-hepatotoxic and neuroprotective agents for Alzheim... | |||
TP1047 | Secretin, porcine TFA (17034-34-3 free base) | Porcine secretin TFA,Secretin, porcine TFA | |
Secretin, porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid.Secretin porcine stimulates panc... | |||
T70646 | Deltarasin HCl | ||
Deltarasin is a high affinity PDEδ-KRAS interaction inhibitor. Deltarasin can inhibit KRAS-PDEδ interactions by binding to a hydrophobic pocket on PDEδ, resulting in the impairment of cell growth, KRAS activity, and RAS/... | |||
T62748 | Nampt-IN-9 | ||
Nampt-IN-9 (Compound 8) is a potent inhibitor of NAMPT with anticancer properties.Nampt-IN-9 can be used to study ductal adenocarcinoma of the pancreas. | |||
T70223 | UA8967 | ||
UA8967 is a membrane-active anti-tumor agent. Cytotoxicity studies in six pancreatic cancer cell lines, one normal human pancreatic ductal epithelial line and two colon cancer cells showed the IC50s UA8967 ranged from 12... | |||
TP1048 | Secretin, porcine | Porcine secretin acetate | |
Secretin, porcine (Porcine secretin acetate) is a 27-amino acid peptide, acting on pancreatic acinar cells and ductal epithelial cells stimulating the production of bicarbonate rich fluid. Secretin porcine stimulates pan... | |||
T75973 | Secretin, porcine TFA | ||
Secretin, Porcine TFA (Porcine secretin TFA) is a 27-amino acid peptide that targets pancreatic acinar and ductal epithelial cells, inducing the secretion of bicarbonate-rich fluid [1]. | |||
T82673 | CPF-7 | Caerulein precursor fragment | |
CPF-7 (Caerulein precursor fragment), an insulinotropic peptide, promotes insulin secretion and drives epithelial-mesenchymal transition via Snai1 upregulation in PANC-1 ductal cells. Moreover, it induces exocrine plasti... | |||
T79689 | SIRT6-IN-3 | Sirtuin | |
SIRT6-IN-3 (compound 8a), a selective SIRT6 inhibitor (IC50 = 7.49 μM), impedes the proliferation of pancreatic ductal adenocarcinoma (PDAC) cells and prompts apoptosis. It enhances the responsiveness of cancer cells to ... | |||
T72355 | KRAS G12D inhibitor 16 | ||
KRAS G12D Inhibitor 16 is a potent compound targeting the KRAS G12D and its mutation, exhibiting inhibitory activity with IC50 values of 0.7 nM and 0.35 μM, respectively. It is utilized in researching various malignant t... | |||
T63902 | XP-524 | ||
XP-524 is a potent inhibitor of BET and EP300. XP-524 has significant tumouricidal effects in vivo, preventing KRAS-induced tumour transformation in vivo and prolonging survival in two aggressive PDAC transgenic mouse mo... | |||
T83880 | C18 Ceramide-1-phosphate (d18:1/18:0) ammonium | Ceramide-1-phosphate (d18:1/18:0),N-octadecanoyl-D-erythro-Sphingosine-1-phosphate,C18 Ceramide-1-phosphate,C18 C1P,CerP(d18:1/18:0),N-stearoyl-D-erythro-Sphingosine-1-phosphate | |
C18 Ceramide-1-phosphate (d18:1/18:0) is a long-chain molecule identified in murine skin known to promote the migration of mouse bone marrow-derived multipotent stromal cells and human umbilical vein endothelial cells (H... | |||
T36103 | TW9 | TW9 | |
TW9 is a dual inhibitor of bromodomain 2 (BD2) in bromodomain-containing protein 4 (BRD4) and histone deacetylase 1 (HDAC1; IC50s = 0.074 and 0.29 μM, respectively).1It is selective for BD2 over BD1 in BRD4 (IC50= 0.72 μ... |
Cat No. | Product Name | Synonyms | Targets |
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T36179 | Aspulvinone O | ||
Aspulvinone O is a fungal metabolite that has been found in P. variotti and has antioxidant and anticancer activities.1,2 It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 11.6 μM).1 Aspulv... |
Cat No. | Product Name | Species | Expression System |
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TMPY-02154 | FAP Protein, Human, Recombinant (His) | Human | HEK293 |
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S... | |||
TMPY-04962 | FAP Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S... | |||
TMPY-04922 | FAP Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S... | |||
TMPK-00721 | CX3CL1/Fractalkine Protein, Mouse, Recombinant (His & Avi), Biotinylated | Mouse | HEK293 |
Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer... | |||
TMPY-00585 | Annexin A8 Protein, Human, Recombinant (His) | Human | E. coli |
We have previously shown that Annexin A8 (ANXA8) is strongly associated with the basal-like subgroup of breast cancers, including BRCA1-associated breast cancers, and poor prognosis; while in the mouse mammary gland AnxA... | |||
TMPY-01346 | Psoriasin/S100A7 Protein, Human, Recombinant | Human | E. coli |
Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can b... | |||
TMPH-00228 | BMP-4 Protein, Bovine, Recombinant (GST) | Bovine | E. coli |
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimu... | |||
TMPH-01017 | BMP-4 Protein, Human, Recombinant (His) | Human | E. coli |
Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes, including neurogenesis, vascular development, angiogenesis and osteogenesis. Acts in concert with PTHLH/PTHRP to stimu... | |||
TMPY-02497 | S100A15 Protein, Mouse, Recombinant (His & MBP) | Mouse | E. coli |
Koebnerisin is also known as protein S100-A7A (S100A7A), S100 calcium-binding protein A7-like 1 (S100A7L1) or S100 calcium-binding protein A15 (S100A15). Human S100A7A / S100A15 is a novel member of the S100 family of EF... | |||
TMPY-03571 | TROY Protein, Human, Recombinant (His) | Human | HEK293 |
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc... | |||
TMPY-03194 | TROY Protein, Human, Recombinant (hFc) | Human | HEK293 |
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc... | |||
TMPY-04075 | CLIC1 Protein, Human, Recombinant (His) | Human | E. coli |
Members of the CLIC family are largely soluble proteins that possess the intriguing property of spontaneous insertion into phospholipid bilayers to form integral membrane ion channels. Chloride intracellular channel 1 (C... | |||
TMPY-01388 | TROY Protein, Mouse, Recombinant (His) | Mouse | HEK293 |
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc... | |||
TMPY-05792 | TROY Protein, Mouse, Recombinant (mFc) | Mouse | HEK293 |
Tumor necrosis factor receptor superfamily, member 19 (TNFRSF19), also known as TAJ-alpha or TROY, is a member of the TNF-receptor superfamily. TNFRSF19/TROY expression is detected in the pulmonary epithelium and the duc... | |||
TMPY-01335 | REG1A Protein, Human, Recombinant (His) | Human | HEK293 |
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa... | |||
TMPY-03684 | REG1A Protein, Cynomolgus, Recombinant (hFc) | Cynomolgus | HEK293 |
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa... | |||
TMPY-03092 | REG1A Protein, Rat, Recombinant (hFc) | Rat | HEK293 |
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa... | |||
TMPY-05474 | REG1A Protein, Human, Recombinant (His), Biotinylated | Human | HEK293 |
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa... | |||
TMPY-03639 | REG1A Protein, Cynomolgus, Recombinant (His) | Cynomolgus | HEK293 |
Regenerating (reg) gene encodes protein that has been involved in pancreatic lithogenesis and the regeneration of islet cells and therefore the abnormality of reg genes could be associated with fibrocalculous pancreatopa... | |||
TMPY-06525 | FAP Protein, Human, Recombinant (aa 27-760, His) | Human | Baculovirus-Insect Cells |
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S... | |||
TMPY-06915 | FAP Protein, Human, Recombinant (His & Avi), Biotinylated | Human | HEK293 |
Seprase, also known as 17 kDa melanoma membrane-bound gelatinase , Fibroblast activation protein alpha, Integral membrane serine protease and FAP, is a single-pass type II membrane protein which belongs to thepeptidase S... |
Cat No. | Product Name | ||
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L2191 | Anti-Breast Cancer Compound Library | 1939 compounds | |
A unique collection of 1939 compounds with anti-breast cancer therapeutic activity or targeting breast cancer’s major signaling pathways, can be used for anti-breast cancer drug discovery and mechanism study; |