Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.07 nM and 0.45 nM).
Pack Size | Availability | Price/USD | Quantity |
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10 μg | 4-5 weeks | $ 593.00 |
Description | Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.07 nM and 0.45 nM). |
In vitro | Bryostatin 1 (1 μM; 5 minutes; HT22 cells) treatment successfully recruits Munc13-1 from the cytosol to the plasma membrane. Effects of Bryostatin 1 on the other Munc13 family members, ubMunc13-2 and bMunc13-2, resembled those of Munc13-1 for translocation. The increased level of expression of Munc13-1 following a 24 h incubation with Bryostatin 1 in both HT22 and primary mouse hippocampal cells is observed [1]. Bryostatin 1 can also affect the immune system by modulating dendritic cells (DCs) via TLR4 through the MyD88-independent pathway which favors an anti-inflammatory environment by inducing a type 2 phenotype that promotes the differentiation of CD4+ T-helper (Th) lymphocytes into Th2 versus Th1 effector cells [2]. |
In vivo | Bryostatin 1 (30 μg/kg; i.p.; 3 d per week; for 2 weeks) treatment abolishes the onset of EAE [2]. |
Molecular Weight | 905.03 |
Formula | C47H68O17 |
CAS No. | 83314-01-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Bryostatin 1 83314-01-6 Chromatin/Epigenetic Cytoskeletal Signaling Microbiology/Virology Proteases/Proteasome PKC HIV Protease inhibitor inhibit