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CDK4/6/1 Inhibitor

Catalog No. T10735Cas No. 2099128-41-1
Alias Crozbaciclib

CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM). CDK4/6 inhibitor is a class of compounds used for the treatment of some types of hormone receptor positive, HER2-negative breast cancer, which can block the process of breast cancer cell division and reproduction.

CDK4/6/1 Inhibitor

CDK4/6/1 Inhibitor

Purity: 99.26%
Catalog No. T10735Alias CrozbaciclibCas No. 2099128-41-1
CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM). CDK4/6 inhibitor is a class of compounds used for the treatment of some types of hormone receptor positive, HER2-negative breast cancer, which can block the process of breast cancer cell division and reproduction.
Pack SizePriceAvailabilityQuantity
1 mg$329In Stock
5 mg$798In Stock
10 mg$1,090In Stock
25 mg$1,650In Stock
50 mg$2,230In Stock
100 mg$2,930In Stock
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Purity:99.26%
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Product Introduction

Bioactivity
Description
CDK4/6/1 Inhibitor (Crozbaciclib) is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM). CDK4/6 inhibitor is a class of compounds used for the treatment of some types of hormone receptor positive, HER2-negative breast cancer, which can block the process of breast cancer cell division and reproduction.
Targets&IC50
CDK4:3 nM, CDK4:3 nM , CDK6:1 nM , CDK6:1 nM
In vitro
CDK4/6/1 Inhibitor is an anti-proliferative agent that arrests the U87MG cell line exclusively in G1 (IC50=15.3 nM in the anti-proliferation assay). U87MG cells exposed to varying concentrations of CDK4/6/1 Inhibitor for 24 hours show a dose-related increase in G1 arrest, and a significant increase in the percentage of cells in G1 is found in as little as 13.72 nM of CDK4/6/1 Inhibitor.[1]
In vivo
In an orthotopic xenograft mouse model of glioblastoma multiforme, CDK4/6/1 Inhibitor (3.125 to 50 mg/kg) has tumor growth inhibition values ranging from 62% to 99%, and no significant body weight loss is observed. The increase in life span based on the median survival time of vehicle-treated animals in mice administered a dose of 50 mg/kg is significant at 162%.[1]
AliasCrozbaciclib
Chemical Properties
Molecular Weight488.57
FormulaC28H30F2N6
Cas No.2099128-41-1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: Slightly soluble

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