Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 45.00 | |
10 mg | In stock | $ 77.00 | |
25 mg | In stock | $ 155.00 | |
50 mg | In stock | $ 261.00 | |
100 mg | In stock | $ 444.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | CGP37157 (7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one) is a Na+/Ca2+ exchanger inhibitor, inhibits Na+-induced Ca2+ release from mitochondria in guinea pig heart with IC50 of 0.8 μM. |
Targets&IC50 | Na+, Ca2+ exchanger:0.8 μM |
In vitro | Administration of 10?μM CGP37157 shows an inhibitory effect on mitochondrial Na+/Ca2+ exchanger in cortical neurons, modulating intracellular Ca2+ levels via suppressing voltage-gated calcium channels. Administration of 10?μM CGP37157 in combination with salinomycin significantly attenuates cell viability and increases apoptosis of FaDu and HLaC79 cells. CGP37157 has no inhibitory effect on salinomycin tumor toxicity[2]. Administration of 10?μM CGP37157 reduces NMDA-induced cytosolic and mitochondrial Ca2+ overloads and it also reduces NMDA-induced excitotoxicity, and such an effect is via attenuating mitochondrial damage and calpain activity in neurons[3]. |
Synonyms | 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one |
Molecular Weight | 324.22 |
Formula | C15H11Cl2NOS |
CAS No. | 75450-34-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/mL (200.48 mM)
You can also refer to dose conversion for different animals. More
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CGP37157 75450-34-9 Membrane transporter/Ion channel Na+/Ca2+ Exchanger CGP 37157 Inhibitor CGP-37157 inhibit 7-Chloro-5-(2-chlorophenyl)-1,5-dihydro-4,1-benzothiazepine-2(3H)-one inhibitor