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CIL62

Catalog No. T8468 CAS 117593-36-9

CIL62 is a Caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].

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CIL62, CAS 117593-36-9

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CIL62 is a caspase-3/7-independent inducer of cell death. The mechanism of action of CIL62 is Necrostatin-1 dependent cell death [1].
In vitro	Necrostatin-1 at 19 μM (5 μg/mL) suppresses CIL62, but CIL62 is not suppressed by the ferroptosis inducers (antioxidants or iron-chelators) [1].

Molecular Weight	382.45
Formula	C23H26O5
CAS No.	117593-36-9

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 10 mg/mL (26.15 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Shimada K , Skouta R , Kaplan A , et al. Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis[J]. Nature Chemical Biology, 2016.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CIL62 117593-36-9 Apoptosis Proteases/Proteasome Caspase CIL-62 Inhibitor inhibitor inhibit

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