Powder: -20°C for 3 years | In solvent: -80°C for 1 year
COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 848.00 | |
5 mg | In stock | $ 1,680.00 | |
10 mg | In stock | $ 2,270.00 | |
25 mg | In stock | $ 3,370.00 | |
50 mg | In stock | $ 4,530.00 | |
100 mg | In stock | $ 6,130.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 1,830.00 |
Description | COX-2-IN-2, a selective inducible COX2 inhibitor, exhibits potent inhibition with an IC50 of 0.24 μM. Meanwhile, COX-2-IN-1 functions as an anti-inflammatory agent, demonstrating both anti-inflammatory and analgesic activities. |
Targets&IC50 | COX-2:240 nM |
In vitro | COX-2-IN-2 shows no COX-1 inhibition even at 100μM[1]. |
In vivo | COX-2-IN-2 has oral ED50 values of 0.030 and 0.47mg/kg on adjuvant-induced arthritis and collagen-induced arthritis, respectively, and an ED30 value of 7.4mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay. COX-2-IN-2 shows good analgesic activity and no ulcerogenicity[1]. |
Molecular Weight | 341.36 |
Formula | C17H12FN3O2S |
CAS No. | 134729-13-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (131.83 mM)
You can also refer to dose conversion for different animals. More
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COX-2-IN-2 134729-13-8 Immunology/Inflammation Neuroscience COX COX2IN2 COX 2 IN 2 inhibitor inhibit