store at low temperature,keep away from direct sunlight,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 62.00 | |
5 mg | In stock | $ 299.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 399.00 |
Description | Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems. |
In vitro | Calcimycin mediates mycobacterial killing by inducing intracellular calcium-regulated autophagy in a P2RX7 dependent manner [4]. |
In vivo | Calcimycin (2.5 or 7.5 nM; intrapleurally) induces protein leakage [5]. |
Synonyms | Antibiotic A-23187, A-23187 |
Molecular Weight | 523.62 |
Formula | C29H37N3O6 |
CAS No. | 52665-69-7 |
store at low temperature,keep away from direct sunlight,store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 47 mg/mL (89.76 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Calcimycin 52665-69-7 Apoptosis Autophagy Microbiology/Virology Antibacterial Antibiotic Antifungal phosphorylation Inhibitor Antibiotic A23187 bacteria Antibiotic A-23187 A 23187 Bacterial mycobacterial divalent Antibiotic A 23187 inhibit A23187 A-23187 cation ionophore Gram-positive Fungal inhibitor