divalent

Edetic acid (Ethylenediaminetetraacetic acid) is a chelating agent commonly used in protein purification, both to eliminate contaminating divalent cations and to inhibit protease activity.

Framycetin sulfate (Neomycin Sulphate B) belongs to aminoglycoside class of antibiotics that contain two or more aminosugars connected by glycosidic bonds.

Phytic acid sodium salt (Sodium phytate hydrate) is known to function as a [PO4]3- storage depot and a precursor for other inositol phosphates and pyrophosphates. It is a potent chelator of divalent and trivalent cations in vitro.

Lanthanum(III) chloride is an inorganic compound which used in biochemical research to block the activity of divalent cation channels, especially calcium channels.

DMT1 blocker 1 is a blocker of divalent metal transporter 1 (DMT1) with IC50 of 0.64 μM, which is expected to block the absorption of iron by intestinal cells in vivo.

lonomycin calcium is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. also induces the activation of protein kinase C (PKC). Ionomycin calcium (SQ23377 calcium) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin promotes apoptosis.

Surfactin is a potent cyclic lipopeptide biosurfactants that mediates flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes, with anti-bacterial, anti-fungal, antimycoplasma and hemolytic effects.

Calcimycin (A-23187) hemicalcium salt is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). It induces Ca2+-dependent cell death by increasing intracellular calcium concentration.

Calcimycin (A-23187) hemimagnesium, an antibiotic and divalent cation ionophore (such as calcium and magnesium), serves various biological roles. It triggers Ca2+-dependent cell death by elevating intracellular calcium levels and suppresses the growth of Gram-positive bacteria and certain fungi. Additionally, this compound hinders ATPase activity and uncouples oxidative phosphorylation (OXPHOS) in mammalian cells, ultimately leading to apoptosis [1] [2] [3] [4].

DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.

Acetate kinase (ACK), an enzyme prevalent in bacteria and archaea, catalyzes the phosphorylation of acetate in the presence of ATP and divalent cations, facilitating the production of acetyl-CoA. It is frequently utilized in biochemical research [1].

Calcimycin (A-23187) is an ionophorous, polyether carboxylic antibiotic from Streptomyces chartreusensis. It binds and transports calcium and other divalent cations across membranes and uncouples oxidative phosphorylation while inhibiting ATPase of rat liver mitochondria. The substance is used mostly as a biochemical tool to study the role of divalent cations in various biological systems.

Nitrilotriacetic acid (Nitriloacetate) is a chelator that tracks and enriches His-tagged proteins in living cells by reacting with divalent metal ions-mediated 6His tagging.

Miridesap (GSK2315698) is a divalent crosslinker of SAP that causes rapid depletion of circulating SAP via hepatic clearance. It also produces significant reduction of SAP from cerebrospinal fluid and visceral amyloid deposits

Bacitracin complex is a bacitracin antibiotic complex composed of cyclic dipeptides that has been found inBacillus.1It is metal-dependent and is complexed to a divalent metal cation, such as Cu2+, Ni2+, Co2+, Zn2+, or Mn2+, for its activity.1,2Bacitracin complex is a mixture of bacitracin polypeptides in complex with copper. 1.Piacham, T., Isarankura-Na-Ayudhya, C., Nantasenamat, C., et al.Metalloantibiotic Mn(II)-bacitracin complex mimicking manganese superoxide dismutaseBiochem. Biophys. Res. Commun.341(4)925-930(2006) 2.Rodríguez-Uribe, N.A., Pérez-González, R., Domínguez-Mendoza, B.E., et al.Metallobacitracins: Affinity and structural study in aqueous solutionInorg. Chem. Commun.10461-70(2019)