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DMT1 blocker 2

🥰Excellent
Catalog No. T11064Cas No. 1062648-63-8

DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.

DMT1 blocker 2

DMT1 blocker 2

🥰Excellent
Purity: 99.68%
Catalog No. T11064Cas No. 1062648-63-8
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.
Pack SizePriceAvailabilityQuantity
1 mg$84In Stock
5 mg$198In Stock
10 mg$372In Stock
25 mg$629In Stock
50 mg$896In Stock
100 mg$1,220In Stock
1 mL x 10 mM (in DMSO)$226In Stock
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Purity:99.68%
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Product Introduction

Bioactivity
Description
DMT1 blocker 2, compound 12f, is a direct inhibitor of divalent metal transporter 1 (DMT1) with an IC50 hydrogen peroxide value of 0.83, which is expected to block iron uptake by intestinal epithelial cells in vivo.
Targets&IC50
DMT1:0.83μM
In vitro
IC50: 0.83 μM (DMT1 blocker 2)
Chemical Properties
Molecular Weight263.29
FormulaC16H13N3O
Cas No.1062648-63-8
SmilesOc1c-2c(CCc3ccccc-23)nn1-c1ccccn1
Relative Density.1.35 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 48 mg/mL (182.3 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7981 mL18.9905 mL37.9809 mL189.9047 mL
5 mM0.7596 mL3.7981 mL7.5962 mL37.9809 mL
10 mM0.3798 mL1.8990 mL3.7981 mL18.9905 mL
20 mM0.1899 mL0.9495 mL1.8990 mL9.4952 mL
50 mM0.0760 mL0.3798 mL0.7596 mL3.7981 mL
100 mM0.0380 mL0.1899 mL0.3798 mL1.8990 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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Keywords

uptakeironmetalDMT1 blocker 2DMT1transporterdivalentDMT-1 blocker 2Inhibitorinhibitenterocytesdirect
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