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Cedrelone

Catalog No. TN3616 CAS 1254-85-9

Cedrelone is a citrulline analog and a phenazine biosynthesis-like domain protein (PBLD) activator.Cedrelone induces apoptosis in cancer cells.Cedrelone is a very potent inducer of apoptosis, causing cell cycle arrest.Cedrelone has insecticidal activity, inhibiting the growth of arrowhead venom of P. saucia and inhibiting moulting of the milkweed bug (Oncopeltus fasciatus). Cedrelone has insecticidal activity, inhibiting the growth of P. saucia and inhibiting moulting of the milkweed bug (Oncopeltus fasciatus).Cedrelone has antitumor effects and exhibits significant cytotoxicity against cancer cell lines such as -60, SMMC-7721, A-549, MCF-7, and SW480.Cedrelone is a very potent inducer of apoptosis, causing cell cycle arrest.Cedrelone is a very potent inducer of apoptosis, leading to cell cycle arrest.

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Cedrelone, CAS 1254-85-9

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Purity: 98%

Biological Description

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Description

In vitro

Cedrelone (1-1000 μM) is a limonoid isolated from Trichilia catigua (Meliaceae) which is a native Brazilian plant. This study demonstrates that Cedrelone inhibits proliferation, adhesion, migration, and invasion of breast tumor cells from the line MDA-MB-231. The effects of cell migration and invasion on MDA-MB-231 cells may be explained, at least in part, by the ability of Cedrelone to inhibit MMP activity. We also demonstrate that Cedrelone is able to induce apoptosis in MDA-MB-231 cells.[1]

Molecular Weight	422.51
Formula	C26H30O5
CAS No.	1254-85-9

Storage

keep away from direct sunlight,store at low temperature

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Fuzer AM, et al. Effects of limonoid cedrelone on MDA-MB-231 breast tumor cells in vitro. Anticancer Agents Med Chem. 2013;13(10):1645-1653. 2. Gopalakrishnan G, et al. Photooxidation of cedrelone, a tetranortriterpenoid from Toona ciliata. Photochem Photobiol. 2000;72(4):464-466. 3. Cao Y, et al. Antitumor activity of Cedrelone in temozolomide-resistant human glioma cells is accompanied by mitochondrial mediated apoptosis, inhibition of angiogenesis, cell cycle disruption and modulation of ERK/MAPK signalling pathway. J BUON. 2019;24(3):1204-1209. 4. Wu J, et al. Novel compound cedrelone inhibits hepatocellular carcinoma progression via PBLD and Ras/Rap1. Exp Ther Med. 2019;18(6):4209-4220.

Citations

1. Wu J, Niu Q, Yuan J, et al. Novel compound cedrelone inhibits hepatocellular carcinoma progression via PBLD and Ras/Rap1. Experimental and Therapeutic Medicine.. 18.6 (2019): 4209-4220

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Cedrelone 1254-85-9 Apoptosis Microbiology/Virology Proteases/Proteasome MMP Antifection Inhibitor inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.