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Cilobradine hydrochloride

Catalog No. T10813 CAS 186097-54-1

Synonyms: DK-AH 269

Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.

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Cilobradine hydrochloride Chemical Structure

Cilobradine hydrochloride, CAS 186097-54-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 238.00
10 mg	In stock	$ 358.00
25 mg	In stock	$ 593.00
50 mg	In stock	$ 847.00
100 mg	In stock	$ 1,130.00

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Purity: 97.46%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Cilobradine hydrochloride (DK-AH 269) is an HCN Channel blocker and an open channel blocker of neuronal Ih and related cardiac If channels.

In vitro

Cilobradine hydrochloride is an HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, Cilobradine hydrochloride inhibits WT mHCN2 channel current by 86%. In contrast, I432A and A425G channel currents were only reduced by 14% and 19%, respectively, by this concentration of Cilobradine hydrochloride. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM Cilobradine hydrochloride (8 ± 2% inhibition)[1].

Synonyms	DK-AH 269
Molecular Weight	519.07
Formula	C28H39ClN2O5
CAS No.	186097-54-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 112.5mg/mL (216.7mM)

H2O: 91 mg/mL (175.31mM)

References and Literature

1. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Drug Repurposing Compound Library Inhibitor Library Bioactive Compounds Library Max Clinical Compound Library Anti-Cancer Compound Library Bioactive Compound Library

Related Products

Related compounds with same targets

ZD7288 Zatebradine hydrochloride

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Keywords

Cilobradine hydrochloride 186097-54-1 Membrane transporter/Ion channel HCN Channel Cilobradine Hydrochloride DK-AH269 DK-AH-269 DK-AH 269 inhibitor inhibit

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