Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
500 mg | In stock | $ 41.00 | |
1 g | In stock | $ 59.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 45.00 |
Description | Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria. |
In vivo | Ciprofloxacin (1 mg/L) induces GST activity, in contrast with inhibited GST and CAT of larvae exposed to enrofloxacin. Ciprofloxacin (≥10 μg/L) and enrofloxacin are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[4]. Ciprofloxacin (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2]. In a murine model of pneumonic plague, ciprofloxacin (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in humans following a 500 mg dose of oral ciprofloxacin. Intraperitoneal ciprofloxacin reduces the lung bacterial load compared to controls treated with intraperitoneal PBS[5]. |
Kinase Assay | The in vitro kinase assays is performed by incubating purified kinase (IKKε or TBK1) in kinase buffer containing 25 mM Tris (pH7.5), 10 mM MgCl2, 1 mM DTT, and 10 μM ATP for 30 minutes at 30°C in the presence of 0.5 μCi γ-[32P]-ATP and 1 μg MBP per sample as a substrate. The kinase reaction is stopped by adding 4x sodium dodecyl sulfate (SDS) sample buffer and boiling for 5 minutes at 95°C. Supernatants are resolved by SDS-polyacrylamide gel electrophoresis, transferred to nitrocellulose, and analyzed by autoradiography using a Typhoon 9410 phosphorimager. |
Synonyms | Ciproxan, Ciprobay, Bay o 9867, Bay-09867 |
Molecular Weight | 331.34 |
Formula | C17H18FN3O3 |
CAS No. | 85721-33-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: Insoluble
DMSO: 0.33 mg/mL (1 mM), Sonification is recommended
0.1 M HCl: 2 mg/mL (6.04 mM), Sonification is recommended
You can also refer to dose conversion for different animals. More
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Ciprofloxacin 85721-33-1 DNA Damage/DNA Repair Microbiology/Virology Topoisomerase Antibacterial Antibiotic Bay 09867 Bacterial Apoptosis Reactive Oxygen Species anti-proliferative Inhibitor mitochondrial inhibit ROS Bay09867 Ciproxan Mitochondrial Metabolism DNA damage DNA Ciprobay Bay o 9867 Bay-09867 inhibitor