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Ciprofloxacin

Catalog No. T1640   CAS 85721-33-1
Synonyms: Ciproxan, Ciprobay, Bay o 9867, Bay-09867

Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Ciprofloxacin Chemical Structure
Ciprofloxacin, CAS 85721-33-1
Pack Size Availability Price/USD Quantity
500 mg In stock $ 41.00
1 g In stock $ 59.00
1 mL * 10 mM (in DMSO) In stock $ 45.00
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Purity: 99.89%
Purity: 99.65%
Purity: 98.77%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria.
In vivo Ciprofloxacin (1 mg/L) induces GST activity, in contrast with inhibited GST and CAT of larvae exposed to enrofloxacin. Ciprofloxacin (≥10 μg/L) and enrofloxacin are ecotoxic for development, growth, detoxifying, and oxidative stress enzymes in anuran amphibian larvae[4]. Ciprofloxacin (CIP) shows potent activity against Y. pestis with MIC90 of 0.03 μg/mL[2]. In a murine model of pneumonic plague, ciprofloxacin (30 mg/kg, i.p.) results in a drug exposure which is similar to the drug exposure observed in humans following a 500 mg dose of oral ciprofloxacin. Intraperitoneal ciprofloxacin reduces the lung bacterial load compared to controls treated with intraperitoneal PBS[5].
Kinase Assay The in vitro kinase assays is performed by incubating purified kinase (IKKε or TBK1) in kinase buffer containing 25 mM Tris (pH7.5), 10 mM MgCl2, 1 mM DTT, and 10 μM ATP for 30 minutes at 30°C in the presence of 0.5 μCi γ-[32P]-ATP and 1 μg MBP per sample as a substrate. The kinase reaction is stopped by adding 4x sodium dodecyl sulfate (SDS) sample buffer and boiling for 5 minutes at 95°C. Supernatants are resolved by SDS-polyacrylamide gel electrophoresis, transferred to nitrocellulose, and analyzed by autoradiography using a Typhoon 9410 phosphorimager.
Synonyms Ciproxan, Ciprobay, Bay o 9867, Bay-09867
Molecular Weight 331.34
Formula C17H18FN3O3
CAS No. 85721-33-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 0.33 mg/mL (1 mM), Sonification is recommended

0.1 M HCl: 2 mg/mL (6.04 mM), Sonification is recommended

TargetMolReferences and Literature

1. Wise R, et al. Antimicrob Agents Chemother, 1983, 23(4), 559-564. 2. Pan XS, et al. Antimicrob Agents Chemother, 1996, 40(10), 2321-2326. 3. Lacy MK, et al. Antimicrob Agents Chemother, 1999, 43(3), 672-677. 4. Peltzer PM, et al. Ecotoxicity of veterinary enrofloxacin and ciprofloxacin antibiotics on anuran amphibian larvae. Environ Toxicol Pharmacol. 2017 Feb 4. pii: S1382-6689(17)320029-7. 5. Hamblin KA, et al. Inhaled Liposomal Ciprofloxacin Protects against a Lethal Infection in a Murine Model of Pneumonic Plague. Front Microbiol. 2017 Feb 6;8:91. 6. Steenbergen J, et al. In Vitro and In Vivo Activity of Omadacycline Against Two Biothreat Pathogens: Bacillus anthracis and Yersinia pestis. Antimicrob Agents Chemother. 2017 Feb 21.

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library Approved Drug Library Anti-Bacterial Compound Library Bioactive Compound Library Inhibitor Library Bioactive Compounds Library Max Orally Active Compound Library Antibiotics Library FDA-Approved & Pharmacopeia Drug Library Clinical Compound Library

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Keywords

Ciprofloxacin 85721-33-1 DNA Damage/DNA Repair Microbiology/Virology Topoisomerase Antibacterial Antibiotic Bay 09867 Bacterial Apoptosis Reactive Oxygen Species anti-proliferative Inhibitor mitochondrial inhibit ROS Bay09867 Ciproxan Mitochondrial Metabolism DNA damage DNA Ciprobay Bay o 9867 Bay-09867 inhibitor

 

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