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Cornuside

Catalog No. T4S2326   CAS 131189-57-6
Synonyms: 7-Galloylsecologanol, 7-O-Galloylsecologanol, Comuside

1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.

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Cornuside Chemical Structure
Cornuside, CAS 131189-57-6
Pack Size Availability Price/USD Quantity
1 mg In stock $ 97.00
5 mg In stock $ 277.00
10 mg In stock $ 437.00
25 mg In stock $ 713.00
50 mg In stock $ 985.00
100 mg In stock $ 1,320.00
500 mg In stock $ 2,660.00
1 mL * 10 mM (in DMSO) In stock $ 353.00
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Purity: 100%
Purity: 99.57%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description 1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
Source
Synonyms 7-Galloylsecologanol, 7-O-Galloylsecologanol, Comuside
Molecular Weight 542.49
Formula C24H30O14
CAS No. 131189-57-6

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 65 mg/mL (119.82 mM)

Pyridine, Methanol, etc.: Soluble

Ethanol: Soluble

TargetMolReferences and Literature

1. Choi Y H , Jin G Y , Li G Z , et al. Cornuside Suppresses Lipopolysaccharide-Induced Inflammatory Mediators by Inhibiting Nuclear Factor-Kappa B Activation in RAW 264.7 Macrophages[J]. Biological & Pharmaceutical Bulletin, 2011, 34(7):959-966.

TargetMolCitations

1. Zhang J, Peng J, Zhang T, et al.Identification of the Main Chemical constituents and mechanism of Renshen Guben oral liquid against Renal Fibrosis.Chinese Medicine.2023, 18(1): 1-14.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Anti-Cancer Compound Library Covalent Inhibitor Library Chinese Pharmacopoeia Natural Product Library Tibetan medicine Compound Library Traditional Chinese Medicine Monomer Library Apoptosis Compound Library Anti-Colorectal Cancer Traditional Chinese Medicine Compound Library Natural Product Library for HTS Antioxidant Compound Library

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ERK-IN-2 Pseudoginsenoside Rh2 Cearoin Bohemine ZINC12409120 AX-15836 A-674563 2HCl(552325-73-2(fb-2hcl)) NMDAR/TRPM4-IN-2

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Keywords

Cornuside 131189-57-6 MAPK NF-Κb JNK ERK NF-κB p38 MAPK Inhibitor 7-Galloylsecologanol 7-O-Galloylsecologanol Nuclear factor-kappaB inhibit Nuclear factor-κB Comuside inhibitor

 

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