keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 277.00 | |
10 mg | In stock | $ 437.00 | |
25 mg | In stock | $ 713.00 | |
50 mg | In stock | $ 985.00 | |
100 mg | In stock | $ 1,320.00 | |
500 mg | In stock | $ 2,660.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 353.00 |
Description | 1. Cornuside (Comuside) has immunomodulatory activity . 2. Cornuside suppresses expression levels of cytokine-induced proinflammatory and adhesion molecules in the human endothelial cells. 3. Cornuside can treat myocardial I/R and protect the liver from CCl4-induced acute hepatotoxicity, by reducing oxidative stress and suppressing inflammatory responses. 4. Cornuside has anti-inflammatory activity by downregulations of iNOS and COX-2 due to NF-κB inhibition as well as the negative regulation of ERK1/2, p38, and JNK1/2 phosphorylations in RAW 264.7 cells. 5. Cornuside has protective potential against cerebral ischemic injury, may be due to the suppression of intracellular Ca(2+) elevation and caspase-3 activity, and improvements in mitochondrial energy metabolism and antioxidant properties. |
Source |
Synonyms | 7-Galloylsecologanol, 7-O-Galloylsecologanol, Comuside |
Molecular Weight | 542.49 |
Formula | C24H30O14 |
CAS No. | 131189-57-6 |
keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 65 mg/mL (119.82 mM)
Pyridine, Methanol, etc.: Soluble
Ethanol: Soluble
You can also refer to dose conversion for different animals. More
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Cornuside 131189-57-6 MAPK NF-Κb JNK ERK NF-κB p38 MAPK Inhibitor 7-Galloylsecologanol 7-O-Galloylsecologanol Nuclear factor-kappaB inhibit Nuclear factor-κB Comuside inhibitor