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Cycloheterophyllin

Catalog No. TN1542 CAS 36545-53-6

Cycloheterophyllin has an antioxidant effect, it is a photoprotective agent that inhibits ultraviolet A (UVA)-induced oxidative stress and damage, and could be used in the research on and prevention of skin photoaging.

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Cycloheterophyllin, CAS 36545-53-6

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Purity: 98%

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Description

In vitro

Extending the aforementioned investigations, in this study, human dermal fibroblasts were used to investigate the protective effect of Cycloheterophyllin against UV-induced damage. We found that Cycloheterophyllin not only significantly increased cell viability, but also attenuated the phosphorylation of MAPK after UVA exposure. Furthermore, Cycloheterophyllin could reduce hydrogen peroxide (H2O2) generation and down-regulate H2O2-induced MAPK phosphorylation. In the in vivo studies, the topical application of Cycloheterophyllin before UVA irradiation significantly decreased trans-epidermal water loss (TEWL), erythema, and blood flow rate[1]

Molecular Weight	502.56
Formula	C30H30O7
CAS No.	36545-53-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Photoprotective Effects of Cycloheterophyllin against UVA-Induced Damage and Oxidative Stress in Human Dermal Fibroblasts.PLoS One. 2016 Sep 1;11(9):e0161767.

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Keywords

Cycloheterophyllin 36545-53-6 表观遗传蛋白酪氨酸激酶免疫与炎症细胞骨架 NADPH-oxidase PKC PKA Inhibitor inhibitor inhibit

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