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Cyfluthrin

Catalog No. T37688   CAS 68359-37-5

Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests.

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Cyfluthrin Chemical Structure
Cyfluthrin, CAS 68359-37-5
Pack Size Availability Price/USD Quantity
5 mg In stock $ 50.00
10 mg In stock $ 70.00
25 mg In stock $ 114.00
50 mg In stock $ 167.00
100 mg In stock $ 248.00
500 mg In stock $ 535.00
1 mL * 10 mM (in DMSO) In stock $ 68.00
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Cyfluthrin binds to voltage-sensitive sodium channel such as Nav 1.8 sodium channel and modify their gating kinetics, thereby disrupting nerve function of pests.
Targets&IC50 ROS:19.39 μM
In vitro Cell viability MTT assay was carried out to assess cyfluthrin cytotoxicity; IC30 and IC50 values for cyfluthrin were calculated to be 4.81 ± 0.92 μM and 19.39 ± 3.44 μM, respectively. Cyfluthrin increased significantly gene expressions of apoptosis, proinflammation and oxidative stress (Bax, Bcl-2, Casp-3, BNIP3, AKT1, p53, APAF1, NFκB1, TNFα and Nrf2) mediators. In the most genes, the mRNA levels induced by cyfluthrin were partially reduced by MEL (1 μM)[1].
Molecular Weight 434.29
Formula C22H18Cl2FNO3
CAS No. 68359-37-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Chloroform: Slightly soluble

Methanol: Heated

DMSO: 55 mg/mL (126.64 mM)

TargetMolReferences and Literature

1. María-Aránzazu Martínez, et al. Oxidative Stress and Related Gene Expression Effects of Cyfluthrin in Human Neuroblastoma SH-SY5Y Cells: Protective Effect of Melatonin. Environ Res. 2019 Oct;177:108579. 2. Jin-Sung Choi,et al.Structure-activity Relationships for the Action of 11 Pyrethroid Insecticides on Rat Na v 1.8 Sodium Channels Expressed in Xenopus Oocytes.Toxicol Appl Pharmacol. 2006 Mar 15;211(3):233-44. 3. Prabhaker, N., Morse, J.G., Castle, S.J., et al.Toxicity of seven foliar insecticides to four insect parasitoids attacking citrus and cotton pestsJ. Econ. Entomol.100(4)1053-1061(2007) 4. Chang, K.-S., Yoo, D.-H., Shin, E.-H., et al.Susceptibility and resistance of field populations of Anopheles sinensis (Diptera: Culicidae) collected from Paju to 13 insecticidesOsong Public Health Res. Perspect.4(2)76-80(2013) 5. Oliver, C.J., Softley, S., Williamson, S.M., et al.Pyrethroids and nectar toxins have subtle effects on the motor function, grooming and wing fanning behaviour of honeybees (Apis mellifera)PLoS One10(8):e0133733(2015)

Related compound libraries

This product is contained In the following compound libraries:
Bioactive Compounds Library Max Ion Channel Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library ReFRAME Related Library Cuproptosis Compound Library Anti-Ovarian Cancer Compound Library Immunology/Inflammation Compound Library NF-κB Signaling Compound Library Mitochondria-Targeted Compound Library

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Keywords

Cyfluthrin 68359-37-5 Immunology/Inflammation Membrane transporter/Ion channel Metabolism NF-Κb Reactive Oxygen Species Sodium Channel Na channels veterinary medicine,agriculture grasshopper,pest,pyrethroid Na+ channels Inhibitor insecticide,stored product inhibit inhibitor

 

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