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D3-βArr
🥰Excellent
Catalog No. T5383Cas No. 662164-09-2
Alias NCGC00379308
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
D3-βArr
🥰Excellent
Purity: 98.82%
Catalog No. T5383Alias NCGC00379308Cas No. 662164-09-2
D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $40 | In Stock | |
| 10 mg | $68 | In Stock | |
| 25 mg | $147 | In Stock | |
| 50 mg | $247 | In Stock | |
| 100 mg | $367 | In Stock | |
| 500 mg | $862 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $44 | In Stock |
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Purity:98.82%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | D3-βArr (NCGC00379308) is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 (EC50: 11.6 μM) by direct TSHR activation. |
| Targets&IC50 | TSHR:11.6 μM(EC50) |
| In vitro | D3-βArr stimulated β-Arr 1 translocation with an efficacy threefold greater than TSH. The EC50 for β-Arr 1 translocation by D3-βArr was 11.6 μM. D3-βArr (10 μM) increased the efficacy of TSH in the translocation of β-Arr 1 at a maximum of 5.1-fold over TSH alone. |
| Alias | NCGC00379308 |
| Molecular Weight | 333.43 |
| Formula | C20H23N5 |
| Cas No. | 662164-09-2 |
| Smiles | CC(Nc1nc(nc2ccccc12)N1CCNCC1)c1ccccc1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (299.91 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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