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DIDS sodium salt

Catalog No. T18975 CAS 67483-13-0

Synonyms: MDL101114ZA

DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

DIDS sodium salt, CAS 67483-13-0

Pack Size	Availability	Price/USD
10 mg	In stock	$ 33.00
25 mg	In stock	$ 51.00
1 mL * 10 mM (in DMSO)	In stock	$ 30.00

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Purity: 99.34%

Purity: 98.63%

Purity: 97.85%

Purity: 96.97%

Purity: 96.5%

Purity: 96.4%

Purity: 95.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	DIDS sodium salt (MDL101114ZA) is a dual inhibitor of ABCA1 and VDAC1.
In vitro	DIDS (<400 μM) has no evident cytotoxic effect on cell viability Pre-treatment with DIDS at the concentration of 100 and 200 μM result in a prevented effect on ALA-SDT-induced cell death, while dose at 50 μM has no inhibition effect. Pre-treatment with DIDS (100 μM) clearly inhibit caspase-3 and caspase-9 activation [2].

Synonyms	MDL101114ZA
Molecular Weight	498.5
Formula	C16H8N2Na2O6S4
CAS No.	67483-13-0

Storage

keep away from direct sunlight

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (100.30 mM), Sonication is recommended.

References and Literature

1. Tsou CY, et al. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis. Acta Physiol (Oxf). 2014 Apr;210(4):799-810. 2. Chen H, et al. Inhibition of VDAC1 prevents Ca²⁺-mediated oxidative stress and apoptosis induced by 5-aminolevulinic acid mediated sonodynamic therapy in THP-1 macrophages. Apoptosis. 2014 Dec;19(12):1712-26.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compounds Library Max Mitochondria-Targeted Compound Library Bioactive Compound Library NO PAINS Compound Library Anti-Cancer Compound Library Ion Channel Inhibitor Library

Related Products

Related compounds with same targets

Tuvatexib VBIT-12 NSC 15364 Erastin VBIT-4

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

DIDS sodium salt 67483-13-0 Membrane transporter/Ion channel VDAC ABC inhibit DIDS sodium Inhibitor Voltage-dependent anion channel MDL101114ZA DIDS inhibitor

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