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DuP-697
DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 also exhibits anti-angiogenic, anti-inflammatory, antipyretic and apoptotic effects.
Catalog No. T15181Cas No. 88149-94-4
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Purity:100%
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DuP-697
Catalog No. T15181Cas No. 88149-94-4
DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 also exhibits anti-angiogenic, anti-inflammatory, antipyretic and apoptotic effects.
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | DuP-697 is an irreversible, specific COX-2 inhibitor with IC50 values of 10 nM and 800 nM for human COX-2 and COX-1. DuP-697 also exhibits anti-angiogenic, anti-inflammatory, antipyretic and apoptotic effects. |
| Targets&IC50 | COX-2 (human):10 nM, COX-1 (human):800 nM |
| In vitro | METHODS: DuP-697 (0, 12.5, 25, 50, 100, 200 μM, 36 hours) was used to treat K562 or CML cell lines. The effects on cell growth were evaluated by MTT assay, and the effects on cell apoptosis were detected by flow cytometry. RESULTS DuP-697 significantly inhibited the growth of K562 cells and primary CML cells with an IC50 value of 31.7 μM, and induced cell apoptosis in a concentration-dependent manner. [2] |
| In vivo | METHODS: DuP 697 (5 mg/kg, intraperitoneal injection) was used to treat rats 1 hour before thrombin injection to investigate its neurotoxic effects on dopaminergic neuronal degeneration in the substantia nigra (SN) of rats. RESULTS The loss of TH-ip neurons was partially attenuated in the SN of rats treated with DuP-697. [2] |
| Molecular Weight | 411.31 |
| Formula | C17H12BrFO2S2 |
| Cas No. | 88149-94-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 45 mg/mL (109.41 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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