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Elsibucol
🥰Excellent
Catalog No. T31615Cas No. 216167-95-2
Alias UNII-O7T92N1Y8T, AGI-1096, AGI 1096
Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury.
Elsibucol
🥰Excellent
Purity: 98.97%
Catalog No. T31615Alias UNII-O7T92N1Y8T, AGI-1096, AGI 1096Cas No. 216167-95-2
Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 138 € | In Stock | |
| 5 mg | 332 € | In Stock | |
| 10 mg | 503 € | In Stock | |
| 25 mg | 816 € | In Stock | |
| 50 mg | 1.121 € | In Stock | |
| 100 mg | 1.510 € | In Stock | |
| 500 mg | 3.030 € | In Stock |
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Purity:98.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Elsibucol (AGI 1096) is a VCAM1 inhibitor for the study of organ transplant rejection.Elsibucol is a metabolically stable propanol derivative with antioxidant, anti-inflammatory and anti-proliferative properties. It lowers blood cholesterol levels and reduces oxidative stress and inflammatory responses in injured arteries, thereby inhibiting atherosclerosis and protecting endothelial healing after arterial injury. |
| In vitro | Elsibucol(0-20 μM) inhibited the inducible expression of vascular cell adhesion molecule (VCAM)-1, E-selectin, and monocyte chemoattractant protein (MCP)-1 in endothelial cells and tumor necrosis factor (TNF)-alpha and interleukin (IL)-1beta secretion from lipopolysaccharide (LPS)-stimulated peripheral blood mononuclear cells. It also inhibited the serum-stimulated proliferation of aortic smooth muscle cells.[4] |
| In vivo | Elsibucol (0.5%, 1%; feed; arterial injury in rabbits with hypercholesterolemia; 3 weeks) significantly decreases blood total cholesterol, LDLc, and triglyceride levels. This is associated with a significant 46% reduction of neointimal hyperplasia following arterial injury. Interestingly, the effect of Elsibucol on cholesterol levels and neointimal formation appears to be more pronounced than that of probucol. Treatment with Elsibucol is associated with a significant reduction of cellular proliferation (PCNA immunostaining), oxidative stress (nitrotyrosine immunostaining), VCAM-1 expression, and macrophage infiltration in injured arteries. Despite its potent effect on neointimal hyperplasia, Elsibucol does not prevent endothelial healing (Evans blue staining) following arterial injury. CONCLUSIONS: In hypercholesterolemic animals, Elsibucol inhibits atherosclerosis and preserves endothelial healing following arterial injury.[1] |
| Alias | UNII-O7T92N1Y8T, AGI-1096, AGI 1096 |
| Molecular Weight | 602.93 |
| Formula | C35H54O4S2 |
| Cas No. | 216167-95-2 |
| Smiles | O(CCCC(O)=O)C1=C(C(C)(C)C)C=C(SC(SC2=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C2)(C)C)C=C1C(C)(C)C |
| Relative Density. | 1.10 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (82.93 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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