keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 55.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 141.00 | |
25 mg | In stock | $ 236.00 | |
50 mg | In stock | $ 352.00 | |
100 mg | In stock | $ 528.00 |
Description | Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker. |
In vitro | Gap 27 significantly reduces the population of TRAP-positive mononuclear and multinucleated rat osteoclasts on bovine bone slices and decreases the functionality of remaining osteoclasts, as demonstrated by a lower percentage of osteoclasts displaying actin rings among all TRAP-positive cells. Moreover, the area resorbed by these treated cultures is substantially reduced[1]. When applied to the carotid artery, Gap 27 at a concentration of 500 μM effectively eliminates the hyperpolarization response to acetylcholine, but does not affect the response to levcromakalim, indicating a specific inhibition of acetylcholine-induced, endothelium-dependent hyperpolarizations in the guinea-pig-isolated internal carotid artery[2]. |
In vivo | Gap 27 (300 μM) inhibits relaxation by 40% in thoracic aorta and the superior mesenteric artery. Gap 27 also attenuates the endothelium-dependent component of the relaxation induced by ATP in thoracic aorta but did not modify force development in response to PhE[3]. |
Molecular Weight | 1304.53 |
Formula | C60H101N15O17 |
CAS No. | 198284-64-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Insoluble
H2O: 10 mM
You can also refer to dose conversion for different animals. More
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Gap 27 198284-64-9 Cytoskeletal Signaling Gap Junction Protein Gap27 inhibit Inhibitor Gap-27 inhibitor