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IHR-1

Catalog No. T24159Cas No. 548779-60-8
Alias IHR 1

IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.

IHR-1

IHR-1

Purity: 97.02%
Catalog No. T24159Alias IHR 1Cas No. 548779-60-8
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
Pack SizePriceAvailabilityQuantity
2 mg$29In Stock
5 mg$48In Stock
10 mg$77In Stock
25 mg$140In Stock
50 mg$215In Stock
100 mg$323In Stock
200 mg$463In Stock
1 mL x 10 mM (in DMSO)$53In Stock
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Purity:97.02%
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Product Introduction

Bioactivity
Description
IHR-1 is a Potent Smo antagonist (IC50 = 7.6 nM). Selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Blocks Smo accumulation in primary cilium in vitro.
Targets&IC50
Smo:7.6 nM
AliasIHR 1
Chemical Properties
Molecular Weight454.13
FormulaC20H12Cl4N2O2
Cas No.548779-60-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 25 mg/mL (55.05 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2020 mL11.0101 mL22.0201 mL110.1006 mL
5 mM0.4404 mL2.2020 mL4.4040 mL22.0201 mL
10 mM0.2202 mL1.1010 mL2.2020 mL11.0101 mL
20 mM0.1101 mL0.5505 mL1.1010 mL5.5050 mL
50 mM0.0440 mL0.2202 mL0.4404 mL2.2020 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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