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IRL-1620 acetate

Catalog No. T15595L CAS T15595L

Synonyms: IRL-1620 acetate（142569-99-1 free base）

IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.

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IRL-1620 acetate, CAS T15595L

Pack Size	Availability	Price/USD
1 mg	In stock	$ 189.00
5 mg	In stock	$ 469.00
10 mg	In stock	$ 687.00
25 mg	In stock	$ 1,080.00
50 mg	In stock	$ 1,450.00
100 mg	In stock	$ 1,960.00

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Purity: 96.64%

Biological Description

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Description	IRL-1620 acetate is an effective and selective agonist of Endothelin B receptor (ETB) with a Ki of 16 pM which is more selective than ETA with a Ki of 19 μM.
Targets&IC50	ETB receptor:16 pM(Ki), ETA receptor:19 μM(Ki)
In vitro	IRL-1620 acetate is 60 times more selective for the ETB receptor than ET-3 (KiETA/ KiETB=1900)[3].
In vivo	IRL-1620 acetate improves both acquisition (learning) and retention (memory) on the water maze task and enhances angiogenic and neurogenic remodeling. Rats treated with IRL-1620 acetate significantly reduces the cognitive impairment induced by Aβ. IRL-1620 acetate treatment enhances the number of blood vessels labeled with VEGF compared to vehicle treatment[1]. IRL-1620 acetate, restores analgesic tolerance to morphine and oxycodone, but it does not affect morphine and oxycodone induced decrease in NGF/PI3K expression. IRL-1620 acetate attenuates opioid tolerance without the involvement of NGF/PI3K pathway[2]. IRL-1620 acetate (1-100 nM) induces contractions of the guinea pig trachea. The effective concentration that produces 30 % of 60 mM KCI-induced contraction is estimated to be 28 nM for IRL 1620[3]. IRL-1620 acetate (1-100 nM) increases cytosolic Ca2+ in the vascular endothelium ([Ca]E) with little effect on resting muscle tone, and relaxes the norepinephrine-stimulated tone with an increase in [Ca]E, in rat aorta[3].

Synonyms	IRL-1620 acetate（142569-99-1 free base）
Molecular Weight	1881
Formula	C88H121N17O29
CAS No.	T15595L

Storage

keep away from moisture

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Briyal S, et al. Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease. Neuroscience. 2015 Aug 20;301:1-11. 2. Gulati S, et al. Attenuation of opioid tolerance by ETB receptor agonist, IRL-1620, is independent of an accompanied decrease in nerve growth factor in mice. Heliyon. 2017 Jun 7;3(6):e00317. 3. Takai M, et al. A potent and specific agonist, Suc-[Glu9,Ala11,15]-endothelin-1(8-21), IRL 1620, for the ETB receptor. Biochem Biophys Res Commun. 1992 Apr 30;184(2):953-9.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Clinical Compound Library Anti-Cancer Drug Library Peptide Compound Library Bioactive Compounds Library Max Drug Repurposing Compound Library Bioactive Compound Library Neurotransmitter Receptor Compound Library Clinical Compound Library

Related Products

Related compounds with same targets

Endothelin 1 (swine, human) acetate Macitentan BQ-788 Aprocitentan Edonentan BQ-3020 ammonium IRL-1038 acetate BQ-123

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Keywords

IRL-1620 acetate T15595L GPCR/G Protein Endothelin Receptor IRL1620 acetate IRL 1620 Acetate IRL1620 Acetate 142569-99-1 free base IRL-1620 acetate（142569-99-1 free base） IRL-1620 Acetate 142569-99-1 IRL 1620 acetate inhibitor inhibit

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