Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 39.00 | |
5 mg | In stock | $ 64.00 | |
10 mg | In stock | $ 113.00 | |
25 mg | In stock | $ 263.00 | |
50 mg | In stock | $ 428.00 | |
100 mg | In stock | $ 690.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 70.00 |
Description | JNJ-17203212 is a potent and selective antagonist of TRPV1 (human TRPV1 and rat TRPV1, IC50 of 65 nM and 102 nM). |
Targets&IC50 | TRPV1 (human):65 nM , TRPV1 (rat):102 nM |
In vivo | TRPV1 antagonist, JNJ-17203212, reduces sensitivity to luminal distension in both an acute, noninflammatory and a chronic, post-inflammatory rodent model of colonic hypersensitivity.??TRPV1 is involved in the pathogenesis of visceral hypersensitivity and that JNJ-17203212 may be a potential therapeutic agent for functional bowel disorders characterized by abdominal hypersensitivity, such as irritable bowel syndrome[1]. |
Animal Research | Colonic sensitivity was assessed via quantification of VMR to CRD in rats following a single, oral administration of JNJ-17203212 (3, 10 or 30 mg/kg) or vehicle[1]. |
Molecular Weight | 419.32 |
Formula | C17H15F6N5O |
CAS No. | 821768-06-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (238.48 mM)
You can also refer to dose conversion for different animals. More
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JNJ-17203212 821768-06-3 Membrane transporter/Ion channel TRP/TRPV Channel management JNJ17203212 inhibit pain migrainem Transient receptor potential channels JNJ 17203212 TRP Channel Inhibitor inhibitor