store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 92 and 3.3 μM for rat brain constitutive NO synthase and mouse inducible NO synthase, respectively.
Description | L-NIL is a potent and selective inhibitor of inducible NO synthase with IC50s of 92 and 3.3 μM for rat brain constitutive NO synthase and mouse inducible NO synthase, respectively. |
Targets&IC50 | iNOS (mouse):3.3 μM , cNOS (rat brain):92 μM |
In vitro | L-NIL exhibits 28-fold higher selectivity for mouse inducible NOS (miNOS) over rat brain constitutive NOS (rcNOS), with IC50 values of 3.3 pM and 92 pM, respectively. Furthermore, it demonstrates roughly 6 times more potency towards miNOS compared to both L-NMA and L-NNA. The compound effectively inhibits miNOS and rcNOS in a concentration-dependent manner, showcasing significant potency for miNOS. |
In vivo | L-NIL protects the integrity of the tarsal, talus and calcaneus bones as well as the soft tissue surrounding the joint, while adjuvant controls exhibit severe deterioration of these bones and dramatic soft tissue swelling.?L-NIL limits progression of preexisting atherosclerosis in hypercholesterolemic rabbits.?Increased intimal collagen accumulation may participate in iNOS-induced atherosclerosis progression.L-NIL may prove particularly useful in determining the role of nitric oxide production by inducible NOS in models of chronic inflammation (e.g., adjuvant arthritis).?L-NIL suppresses the increase in plasma nitrite levels and joint inflammation associated with adjuvant-induced arthritis in a dose-dependent manner.?L-NIL attenuates the inducible nitric oxide synthase immunoreactivity in adjuvant-treated rats. |
Molecular Weight | 187.24 |
Formula | C8H17N3O2 |
CAS No. | 53774-63-3 |
store at low temperature,keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: < 1 mg/mL (insoluble or slightly soluble)
You can also refer to dose conversion for different animals. More
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L-NIL 53774-63-3 Others L NIL LNIL inhibitor inhibit