Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 64.00 | |
50 mg | In stock | $ 97.00 | |
100 mg | In stock | $ 143.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | LDN-91946 is an effective and selective inhibitor of ubiquitin C-terminal hydrolase-L1 (UCH-L1) (Ki = 2.8 μM). |
Targets&IC50 | UCHL1: 2.8 μM(ki) |
In vitro | LDN-91946 demonstrates no inhibitory activity against TGase 2, Papain, and Caspase-3 at concentrations of 40 μM, and remains inactive against UCH-L3 at 20 μM. Furthermore, it exhibits no cytotoxic effects on serum-starved Neuro 2A (N2A) cells even at concentrations up to 0.1 mM[1]. |
Molecular Weight | 314.32 |
Formula | C15H10N2O4S |
CAS No. | 439946-22-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83 mg/mL (264.06 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. More
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LDN-91946 439946-22-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Ubiquitination DUB LDN91946 Inhibitor Ubiquitin LDN 91946 inhibit Deubiquitinase UCH-L1 DUBs selective inhibitor