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LM22A-4

Catalog No. T7568 CAS 37988-18-4

LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay)

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LM22A-4, CAS 37988-18-4

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Purity: 98%

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Description	LM22A-4 is a brain-derived neurotrophic factor (BDNF) mimetic and agonist of the receptor tropomyosin-related kinase B (TrkB; IC50 : 47 nM in a fluorescence anisotropy assay)
Targets&IC50	TrkB:47 nM
In vitro	In vitro, LM22A-4 increases survival of hippocampal neurons via activation of TrkB as well as Akt and ERK downstream pro-survival signaling pathways[1].
In vivo	Treatment of Het mice with LM22A-4 for 4 weeks rescued wild-type levels of TrkB phosphorylation in the medulla and pons and restored wild-type breathing frequency[1].
Animal Research	Wt and Het littermates were divided into 4 groups: Wt vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), Wt drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.), Het vehicle-treated (100 μl of 0.9% NaCl, i.p., b.i.d.), and Het drug-treated (50 mg/kg LM22A-4 in 0.9% NaCl, i.p., b.i.d.).?Each mouse was treated from 8 to 13 weeks of age.?Whole-body plethysmography was performed during week 12 and animals were subsequently killed and tissues harvested for TrkB Western blots and BDNF ELISA during week[1].

Molecular Weight	339.34
Formula	C15H21N3O6
CAS No.	37988-18-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: 50 mg/mL (147.34 mM)

DMSO: 29 mg/mL (85.46 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Schmid D A , Yang T , Ogier M , et al. A TrkB Small Molecule Partial Agonist Rescues TrkB Phosphorylation Deficits and Improves Respiratory Function in a Mouse Model of Rett Syndrome[J]. The Journal of Neuroscience : The Official Journal of the Society for Neuroscience, 2012, 32(5):1803-1810. 2. Simmons D A , Belichenko N P , Yang T , et al. A Small Molecule TrkB Ligand Reduces Motor Impairment and Neuropathology in R6/2 and BACHD Mouse Models of Huntington\"s Disease[J]. Journal of Neuroscience, 2013, 33(48):18712-18727.

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Keywords

LM22A-4 37988-18-4 Tyrosine Kinase/Adaptors Trk receptor LM-22A-4 Inhibitor Trk Receptor inhibit LM22A4 Tropomyosin related kinase receptor LM22A 4 inhibitor

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