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Limaprost

Limaprost
Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost (17α,20-dimethyl-δ2-PGE1) can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment.
Catalog No. T15757Cas No. 74397-12-9
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Purity:99.89%
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Limaprost

Catalog No. T15757Cas No. 74397-12-9
Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost (17α,20-dimethyl-δ2-PGE1) can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment.
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1 mg$19835 days
10 mg$1,48035 days
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Product Introduction

Bioactivity
Description
Limaprost (17α,20-dimethyl-δ2-PGE1) is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency.It is a potent and orally active vasodilator. Limaprost increases blood flow and inhibits platelet aggregation. Limaprost (17α,20-dimethyl-δ2-PGE1) can be used for pain relief, has antianginal effects, and has potential for ischaemic symptoms treatment.
In vitro
By a concentration-dependent manner, Limaprost inhibits the IL-1-mediated induction of nerve growth factor (IC50: 70.9 ?nM human IVD cells) [3].
In vivo
PGE1 and limaprost exhibited a novel pharmacological action that suppresses NGF expression in human IVD cells, and other prostanoids differentially regulated NGF expression.?Limaprost has been used to treat patients with lumbar spinal stenosis in Japan and was proved to be effective in relieving symptoms.Platelet aggregation, adhesiveness, bleeding time, and thrombocytopenia induced by ADP and collagen infusion in guinea-pigs are inhibited by oral administration of Limaprost at the same doses or doses less than those relieving vasopressin-induced ST depression of ECG.?Intra-coronary injection of Limaprost (1-100 ng/kg) in dogs causes a remarkable increase in coronary blood flow without any influence on heart rate, blood pressure, myocardial oxygen consumption, and redox potential.?Limaprost given orally at more than 100 mg/kg relieves vasopressin-induced ST depression of rat electrocardiogram.?Resistance in both large and small vessels of the dog coronary artery is decreased by intravenous injection of Limaprost (1-3 mg/kg) [1].
Alias17α,20-dimethyl-δ2-PGE1, OP1206, ONO1206
Chemical Properties
Molecular Weight380.52
FormulaC22H36O5
Cas No.74397-12-9
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (105.12 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6280 mL13.1399 mL26.2798 mL131.3991 mL
5 mM0.5256 mL2.6280 mL5.2560 mL26.2798 mL
10 mM0.2628 mL1.3140 mL2.6280 mL13.1399 mL
20 mM0.1314 mL0.6570 mL1.3140 mL6.5700 mL
50 mM0.0526 mL0.2628 mL0.5256 mL2.6280 mL
100 mM0.0263 mL0.1314 mL0.2628 mL1.3140 mL

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